SCHEMBL31738786

SCHEMBL31738786

COC(=O)c1cc2c(cc1CBr)C=CC1(CN(C(=O)OC(C)(C)C)C1)O2

nearest known ligand 0.34

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ EED O75530 1/20 0.34
▸ RBBP4 Q09028 1/20 0.34
▸ SUZ12 Q15022 1/20 0.34
▸ EZH2 Q15910 1/20 0.34
▸ AEBP2 Q6ZN18 1/20 0.34
▸ PKM P14618 1/20 0.34
▸ NR1H2 P55055 1/20 0.32
▸ GPR183 P32249 1/20 0.32
▸ JAK2 O60674 3/20 0.32
▸ JAK1 P23458 3/20 0.32
▸ RORC P51449 1/20 0.30
▸ GPR119 Q8TDV5 1/20 0.30
▸ HTT P42858 1/20 0.30
▸ ATM Q13315 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31192103 0.91 PKM (0.42) EEDRBBP4SUZ12EZH2AEBP2
SCHEMBL31738792 0.87 PKM (0.42) EEDRBBP4SUZ12EZH2AEBP2
SCHEMBL25342550 0.86 EED (0.38) EEDRBBP4SUZ12EZH2AEBP2
SCHEMBL31738793 0.86 EED (0.38) EEDRBBP4SUZ12EZH2AEBP2
SCHEMBL25342925 0.84 EED (0.38) EEDRBBP4SUZ12EZH2AEBP2
SCHEMBL31380537 0.79 NR1H2 (0.34) PKMNR1H2GPR183JAK2JAK1
SCHEMBL25343065 0.77 PKM (0.44) EEDRBBP4SUZ12EZH2AEBP2
SCHEMBL31738778 0.77 PKM (0.44) EEDRBBP4SUZ12EZH2AEBP2
SCHEMBL31543870 0.75 HTR2C (0.40) GPR183RORCGPR119
SCHEMBL25342310 0.74 PKM (0.44) EEDRBBP4SUZ12EZH2AEBP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4656642-A1 ESTROGEN RECEPTOR PROTEOLYSIS TARGETING CHIMERA COMPOUND AND USE THEREOF GAN & LEE PHARM CO., LTD (CN) 2025-12-03 — — EP disclosed
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