SCHEMBL31192103

SCHEMBL31192103

COC(=O)c1cc2c(cc1CBr)C=CC1(CCN(C(=O)OC(C)(C)C)CC1)O2

nearest known ligand 0.42

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ PKM P14618 1/20 0.42
▸ EED O75530 1/20 0.36
▸ RBBP4 Q09028 1/20 0.36
▸ SUZ12 Q15022 1/20 0.36
▸ EZH2 Q15910 1/20 0.36
▸ AEBP2 Q6ZN18 1/20 0.36
▸ GPR119 Q8TDV5 8/20 0.36
▸ JAK2 O60674 3/20 0.35
▸ JAK1 P23458 3/20 0.35
▸ NR1H2 P55055 1/20 0.33
▸ ALOX15 P16050 1/20 0.33
▸ TSHR P16473 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31738792 0.96 PKM (0.42) PKMEEDRBBP4SUZ12EZH2
SCHEMBL31738786 0.91 EED (0.34) PKMEEDRBBP4SUZ12EZH2
SCHEMBL25343065 0.87 PKM (0.44) PKMEEDRBBP4SUZ12EZH2
SCHEMBL31738778 0.87 PKM (0.44) PKMEEDRBBP4SUZ12EZH2
SCHEMBL25342310 0.85 PKM (0.44) PKMEEDRBBP4SUZ12EZH2
SCHEMBL31236104 0.84 PKM (0.41) PKMEEDRBBP4SUZ12EZH2
SCHEMBL31738773 0.80 PKM (0.42) PKMEEDRBBP4SUZ12EZH2
SCHEMBL31024713 0.80 PKM (0.40) PKMGPR119JAK2JAK1NR1H2
SCHEMBL31738784 0.79 GPR119 (0.42) PKMGPR119JAK2JAK1
SCHEMBL30591662 0.77 PKM (0.41) PKMEEDRBBP4SUZ12EZH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4656642-A1 ESTROGEN RECEPTOR PROTEOLYSIS TARGETING CHIMERA COMPOUND AND USE THEREOF GAN & LEE PHARM CO., LTD (CN) 2025-12-03 — — EP disclosed
US-20250129088-A1 CEREBLON E3 UBIQUITIN LIGASE INHIBITOR GAN & LEE PHARMACEUTICALS CO., LTD. (CN) 2025-04-24 — — US disclosed
EP-4471033-A1 CEREBLON E3 UBIQUITIN LIGASE INHIBITOR Gan & Lee Pharmaceuticals Co., Ltd. (CN) 2024-12-04 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250129088-A1 CEREBLON E3 UBIQUITIN LIGASE INHIBITOR CRBN, UBE3A, UBE3C PKM 3582/4885EED 1267/4885RBBP4 260/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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