Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 4/20 | 0.47 |
| ▸ | WEE1 | P30291 | 4/20 | 0.47 |
| ▸ | CDK1 | P06493 | 2/20 | 0.47 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.44 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.44 |
| ▸ | CDK4 | P11802 | 2/20 | 0.44 |
| ▸ | PRKACA | P17612 | 2/20 | 0.44 |
| ▸ | PRKACG | P22612 | 2/20 | 0.44 |
| ▸ | PRKACB | P22694 | 2/20 | 0.44 |
| ▸ | CCND1 | P24385 | 2/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.44 |
| ▸ | CDK2 | P24941 | 2/20 | 0.44 |
| ▸ | CAMK2B | Q13554 | 2/20 | 0.44 |
| ▸ | CAMK2G | Q13555 | 2/20 | 0.44 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.44 |
| ▸ | CAMK2A | Q9UQM7 | 2/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8554507 | 0.99 | SIGMAR1 (0.47) | CHEK1WEE1CDK1TRPM2PARP1 | |
| SCHEMBL8557009 | 0.97 | CHEK1 (0.47) | CHEK1WEE1CDK1TRPM2PARP1 | |
| SCHEMBL8559979 | 0.93 | CHEK1 (0.43) | CHEK1WEE1CDK1TRPM2PARP1 | |
| SCHEMBL8557596 | 0.92 | CHEK1 (0.44) | CHEK1WEE1CDK1TRPM2PARP1 | |
| SCHEMBL8667745 | 0.88 | WEE1 (0.40) | CHEK1WEE1CDK1TRPM2PARP1 | |
| SCHEMBL4910767 | 0.87 | CHEK1 (0.50) | CHEK1WEE1CDK1PARP1SIGMAR1 | |
| SCHEMBL8554694 | 0.86 | CHEK1 (0.49) | CHEK1WEE1CDK1PARP1SIGMAR1 | |
| SCHEMBL8559090 | 0.86 | CHEK1 (0.49) | CHEK1WEE1CDK1PARP1SIGMAR1 | |
| SCHEMBL8558051 | 0.86 | CHEK1 (0.49) | CHEK1WEE1CDK1PARP1SIGMAR1 | |
| SCHEMBL7986525 | 0.84 | CCR3 (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100016343-A1 | ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR INHIBITORS | WYETH (US) | 2010-01-21 | — | — | US | disclosed |
| US-20100016598-A1 | ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR INHIBITORS | WYETH (US) | 2010-01-21 | — | — | US | disclosed |
| US-20100016360-A1 | ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR INHIBITORS | WYETH (US) | 2010-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100016598-A1 | ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR INHIBITORS | CHRNA7, CHRNA6, CHRNA2 | CHEK1 3196/4885WEE1 4126/4885CDK1 2006/4885 |
| US-20100016343-A1 | ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR INHIBITORS | CHRNA7, CHRNA6, CHRNA2 | CHEK1 3196/4885WEE1 4126/4885CDK1 2006/4885 |
| US-20100016360-A1 | ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR INHIBITORS | CHRNA7, CHRNA6, CHRNA2 | CHEK1 3196/4885WEE1 4126/4885CDK1 2006/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.