Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Clemizole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.86 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.86 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.86 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.86 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.86 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.86 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.86 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.86 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.86 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.86 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.86 |
| ▸ | LMNA | P02545 | 1/20 | 0.86 |
| ▸ | ESR1 | P03372 | 1/20 | 0.86 |
| ▸ | PGR | P06401 | 1/20 | 0.86 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.86 |
| ▸ | PKM | P14618 | 1/20 | 0.86 |
| ▸ | TSHR | P16473 | 1/20 | 0.86 |
| ▸ | HTR2A | P28223 | 1/20 | 0.86 |
| ▸ | HRH1 | P35367 | 1/20 | 0.86 |
| ▸ | HTR2B | P41595 | 1/20 | 0.86 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Clemizole SCHEMBL4322963 | 1.00 | HIF1A (0.86) | HIF1ATDP1CYP1A2CYP2D6CYP2C9 | |
| Clemizole SCHEMBL19976079 | 0.95 | HIF1A (0.82) | HIF1ATDP1CYP1A2CYP2D6CYP2C9 | |
| Clemizole SCHEMBL19976086 | 0.93 | HIF1A (0.79) | HIF1ATDP1CYP1A2CYP2D6CYP2C9 | |
| Clemizole SCHEMBL29403196 | 0.93 | HIF1A (1.00) | HIF1ATDP1CYP1A2CYP2D6CYP2C9 | |
| Clemizole SCHEMBL29938 | 0.93 | HIF1A (1.00) | HIF1ATDP1CYP1A2CYP2D6CYP2C9 | |
| Clemizole SCHEMBL19976085 | 0.92 | HIF1A (0.88) | HIF1ATDP1CYP1A2CYP2D6CYP2C9 | |
| Clemizole SCHEMBL19976068 | 0.92 | HIF1A (0.97) | HIF1ATDP1CYP1A2CYP2D6CYP2C9 | |
| Clemizole SCHEMBL210095 | 0.92 | HIF1A (1.00) | HIF1ATDP1CYP1A2CYP2D6CYP2C9 | |
| Clemizole SCHEMBL19976072 | 0.92 | HIF1A (0.97) | HIF1ATDP1CYP1A2CYP2D6CYP2C9 | |
| Clemizole SCHEMBL31707402 | 0.92 | HIF1A (1.00) | HIF1ATDP1CYP1A2CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4667008-A2 | METHODS AND COMPOSITIONS FOR TREATING RNA VIRAL INFECTIONS | Model Medicines, Inc. (US) | 2025-12-24 | — | — | EP | disclosed |