Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of Clemizole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.82 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.82 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.82 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.82 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.82 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.82 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.82 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.82 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.82 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.82 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.82 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.82 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.82 |
| ▸ | LMNA | P02545 | 1/20 | 0.82 |
| ▸ | ESR1 | P03372 | 1/20 | 0.82 |
| ▸ | PGR | P06401 | 1/20 | 0.82 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.82 |
| ▸ | PKM | P14618 | 1/20 | 0.82 |
| ▸ | TSHR | P16473 | 1/20 | 0.82 |
| ▸ | HRH1 | P35367 | 1/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Clemizole SCHEMBL31747751 | 0.95 | HIF1A (0.86) | HIF1ATDP1CYP1A2CYP2D6CYP2C9 | |
| Clemizole SCHEMBL4322963 | 0.95 | HIF1A (0.86) | HIF1ATDP1CYP1A2CYP2D6CYP2C9 | |
| Clemizole SCHEMBL19976086 | 0.91 | HIF1A (0.79) | HIF1ATDP1CYP1A2CYP2D6CYP2C9 | |
| Clemizole SCHEMBL29403196 | 0.91 | HIF1A (1.00) | HIF1ATDP1CYP1A2CYP2D6CYP2C9 | |
| Clemizole SCHEMBL29938 | 0.91 | HIF1A (1.00) | HIF1ATDP1CYP1A2CYP2D6CYP2C9 | |
| Clemizole SCHEMBL19976081 | 0.90 | HIF1A (0.84) | HIF1ATDP1CYP1A2CYP2D6CYP2C9 | |
| Clemizole SCHEMBL19976089 | 0.90 | HIF1A (0.72) | HIF1ATDP1CYP1A2CYP2D6CYP2C9 | |
| Clemizole SCHEMBL19976085 | 0.90 | HIF1A (0.88) | HIF1ATDP1CYP1A2CYP2D6CYP2C9 | |
| Clemizole SCHEMBL19976068 | 0.90 | HIF1A (0.97) | HIF1ATDP1CYP1A2CYP2D6CYP2C9 | |
| Clemizole SCHEMBL31707402 | 0.90 | HIF1A (1.00) | HIF1ATDP1CYP1A2CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11684609-B2 | Compounds and methods for treating an epileptic disorder | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2023-06-27 | — | — | US | claimed |
| EP-3035926-B1 | COMPOUNDS AND METHODS FOR TREATING AN EPILEPTIC DISORDER | UNIV CALIFORNIA (US) | 2020-07-29 | — | — | EP | claimed |
| US-9925172-B2 | Compounds and methods for treating an epileptic disorder | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-03-27 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11684609-B2 | Compounds and methods for treating an epileptic disorder | GABRE, SLC6A1, GABBR1 | ADRA2B 1827/4885HTR2A 970/4885ADRA1A 1510/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.