Stigmastanol

SCHEMBL3175283

CC(C)[C@H](C)CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CCC4CCCC(O)[C@]4(C)[C@H]3CC[C@]12C.CC[C@H](CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C)C(C)C

nearest known ligand 0.54

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	GPBAR1	Q8TDU6	7/20	0.54

▸	CASP7	P55210	3/20	0.54

▸	TDP1	Q9NUW8	3/20	0.54

▸	HIF1A	Q16665	3/20	0.54

▸	EPHA2	P29317	3/20	0.54

▸	TP53	P04637	2/20	0.54

▸	MAPK1	P28482	2/20	0.54

▸	HSD17B10	Q99714	2/20	0.54

▸	BLM	P54132	2/20	0.54

▸	VDR	P11473	2/20	0.54

▸	USP2	O75604	2/20	0.54

▸	CYP3A4	P08684	2/20	0.54

▸	LMNA	P02545	2/20	0.54

▸	TSHR	P16473	2/20	0.54

▸	MDM4	O15151	1/20	0.54

▸	MAPT	P10636	1/20	0.54

▸	HSPD1	P10809	1/20	0.54

▸	PTPN2	P17706	1/20	0.54

▸	PTPN1	P18031	1/20	0.54

▸	BRCA1	P38398	1/20	0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL1248223	0.88	GPBAR1 (0.53)	GPBAR1CASP7TDP1HIF1AEPHA2
SCHEMBL167699	0.88	GPBAR1 (0.53)	GPBAR1CASP7TDP1HIF1AEPHA2
Stigmastanol SCHEMBL12429027	0.88	GPBAR1 (0.69)	GPBAR1CASP7TDP1HIF1AEPHA2
Stigmastanol SCHEMBL18934457	0.88	GPBAR1 (0.69)	GPBAR1CASP7TDP1HIF1AEPHA2
Stigmastanol SCHEMBL13324290	0.88	GPBAR1 (0.69)	GPBAR1CASP7TDP1HIF1AEPHA2
Stigmastanol SCHEMBL3149669	0.88	GPBAR1 (0.69)	GPBAR1CASP7TDP1HIF1AEPHA2
Stigmastanol SCHEMBL133726	0.88	GPBAR1 (0.69)	GPBAR1CASP7TDP1HIF1AEPHA2
Stigmastanol SCHEMBL18508083	0.88	GPBAR1 (0.69)	GPBAR1CASP7TDP1HIF1AEPHA2
Stigmastanol SCHEMBL21927840	0.88	GPBAR1 (0.69)	GPBAR1CASP7TDP1HIF1AEPHA2
Stigmastanol SCHEMBL3149663	0.88	GPBAR1 (0.69)	GPBAR1CASP7TDP1HIF1AEPHA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-7645749-B2	contains ester linkage of a nitric oxide (NO)-releasing moiety to a sterol or stanol compound; useful for treating atherosclerosis, hypercholesterolemia, hyperlipidemia, hypertension, thrombosis, Type II diabetes, dementia, Alzheimer's disease and aging	FORBES MEDI-TECH INC. (CA)	2010-01-12	—	—	US	disclosed
US-20070232580-A1	Novel sterol/stanol nitroderivatives and use thereof in treating or preventing cardiovascular disease, its underlying conditions and other disorders	FORBES MEDI-TECH INC.	2007-10-04	—	—	US	disclosed
EP-1507867-A2	PROCESS FOR FERMENTATION OF PHYTOSTEROLS TO ANDROSTADIENEDIONE	Akzo Nobel N.V. (NL)	2005-02-23	—	—	EP	disclosed
WO-2003064674-A2	PROCESS FOR FERMENTATION OF PHYTOSTEROLS TO ANDROSTADIENEDIONE	AKZO NOBEL N.V. (NL)	2003-08-07	—	—	WO	disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-20070232580-A1	Novel sterol/stanol nitroderivatives and use thereof in treating or preventing cardiovascular disease, its underlying conditions and other disorders	CYP27A1, HSD11B1, NOS1	GPBAR1 224/4885CASP7 900/4885TDP1 1249/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.