Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | FDPS | P14324 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.44 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.44 |
| ▸ | FPR1 | P21462 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22803234 | 0.87 | NLRP3 (0.46) | TBXAS1CYP1A2CYP3A4CYP2C9FDPS | |
| SCHEMBL24918847 | 0.87 | NLRP3 (0.46) | TBXAS1CYP1A2CYP3A4CYP2C9FDPS | |
| SCHEMBL8908045 | 0.84 | NLRP3 (0.48) | CYP1A2CYP3A4CYP2C9FDPSLMNA | |
| SCHEMBL14640282 | 0.84 | TBXAS1 (0.57) | TBXAS1CYP1A2CYP3A4CYP2C9FDPS | |
| SCHEMBL12220088 | 0.84 | TBXAS1 (0.50) | TBXAS1CYP1A2CYP3A4CYP2C9FDPS | |
| SCHEMBL30937414 | 0.84 | TBXAS1 (0.57) | TBXAS1CYP1A2CYP3A4CYP2C9FDPS | |
| SCHEMBL6220905 | 0.84 | TBXAS1 (0.57) | TBXAS1CYP1A2CYP3A4CYP2C9FDPS | |
| SCHEMBL31370303 | 0.84 | TBXAS1 (0.57) | TBXAS1CYP1A2CYP3A4CYP2C9FDPS | |
| SCHEMBL14898388 | 0.84 | TBXAS1 (0.50) | TBXAS1CYP1A2CYP3A4CYP2C9FDPS | |
| SCHEMBL29794529 | 0.84 | TBXAS1 (0.57) | TBXAS1CYP1A2CYP3A4CYP2C9FDPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260001914-A1 | MACROCYCLIC PEPTIDES TARGETING KRAS | MERCK SHARP & DOHME LLC (US) | 2026-01-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260001914-A1 | MACROCYCLIC PEPTIDES TARGETING KRAS | KRAS, NRAS, HRAS | TBXAS1 4519/4885CYP1A2 4664/4885CYP3A4 4761/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.