Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 13/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | GFER | P55789 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3172699 | 0.90 | ALDH1A1 (0.51) | GAAALOX15GFERLMNAMAPT | |
| SCHEMBL3162425 | 0.89 | EGFR (0.53) | GAAGFERLMNAMAPTALDH1A1 | |
| SCHEMBL3175718 | 0.89 | DRD4 (0.51) | GAAALOX15GFERLMNAMAPT | |
| SCHEMBL3175833 | 0.89 | DRD4 (0.51) | GAALMNAMAPTALDH1A1MEN1 | |
| SCHEMBL3166249 | 0.88 | GAA (0.54) | GAAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL3160939 | 0.88 | ALDH1A1 (0.52) | ALOX15LMNAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL3260259 | 0.87 | ALDH1A1 (0.45) | GAAALOX15LMNAMAPTALDH1A1 | |
| SCHEMBL3162900 | 0.87 | MAPT (0.44) | GAAALOX15LMNAMAPTALDH1A1 | |
| SCHEMBL3171920 | 0.87 | ADORA1 (0.47) | ALDH1A1EGFR | |
| SCHEMBL3163144 | 0.86 | ADORA3 (0.46) | LMNAMAPTALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465631-B1 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI PHARM INC (US) | 2010-02-24 | — | — | EP | disclosed |