Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | TSHR | P16473 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 3/20 | 0.47 |
| ▸ | DRD3 | P35462 | 3/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3169692 | 0.92 | ADORA3 (0.47) | DRD4MAPTALDH1A1TSHRKMT2A | |
| SCHEMBL3175773 | 0.89 | GAA (0.55) | MAPTALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3163835 | 0.88 | MEN1 (0.46) | DRD4ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL3172699 | 0.88 | ALDH1A1 (0.51) | MAPTALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL3162425 | 0.87 | EGFR (0.53) | MAPTALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL3175718 | 0.87 | DRD4 (0.51) | DRD4MAPTALDH1A1KDM4EGAA | |
| SCHEMBL3175820 | 0.87 | MEN1 (0.46) | DRD4MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL3165286 | 0.87 | USP2 (0.57) | DRD4MAPTALDH1A1TSHRMEN1 | |
| SCHEMBL3156668 | 0.86 | MAPT (0.59) | DRD4MAPTALDH1A1TSHRMEN1 | |
| SCHEMBL3160939 | 0.85 | ALDH1A1 (0.52) | DRD4ALDH1A1TSHRSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465631-B1 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI PHARM INC (US) | 2010-02-24 | — | — | EP | disclosed |