SCHEMBL317642

SCHEMBL317642

Cc1nc2cc(Cl)c(Cl)cc2n1Cc1ccccc1

nearest known ligand 0.70

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
DCTPP1 Q9H773 4/20 0.70
TNF P01375 1/20 0.67
GALR3 O60755 2/20 0.57
NR2F2 P24468 2/20 0.57
RAB9A P51151 1/20 0.57
PPARG P37231 4/20 0.54
ALDH1A1 P00352 2/20 0.51
KDM4E B2RXH2 1/20 0.51
MEN1 O00255 1/20 0.51
GAA P10253 1/20 0.51
MAPT P10636 1/20 0.51
PKM P14618 1/20 0.51
KMT2A Q03164 1/20 0.51
TDP1 Q9NUW8 1/20 0.51
DHFR P00374 1/20 0.51
BRD4 O60885 1/20 0.48
MAPK1 P28482 1/20 0.48
RHEB Q15382 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22533519 0.86 DCTPP1 (0.68) DCTPP1TNFGALR3NR2F2RAB9A
SCHEMBL17380972 0.86 DCTPP1 (0.69) DCTPP1TNFGALR3NR2F2RAB9A
SCHEMBL8185055 0.84 DCTPP1 (0.50) DCTPP1TNFRAB9AALDH1A1KDM4E
SCHEMBL12771510 0.83 TNF (0.69) TNFGALR3NR2F2RAB9APPARG
SCHEMBL615476 0.82 TNF (0.68) DCTPP1TNFGALR3NR2F2RAB9A
SCHEMBL617824 0.82 TNF (0.68) DCTPP1TNFGALR3NR2F2RAB9A
SCHEMBL10983849 0.81 TNF (0.71) TNFGALR3NR2F2RAB9APPARG
SCHEMBL8191061 0.81 KMT2A (0.63) DCTPP1TNFRAB9AALDH1A1KDM4E
SCHEMBL15741934 0.81 TNF (0.61) DCTPP1TNFGALR3NR2F2RAB9A
SCHEMBL231295 0.80 TNF (1.00) TNFGALR3NR2F2RAB9AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9670476-B2 Enzyme substrate comprising a functional dye and associated technology and methods BIOTIUM, INC. (US) 2017-06-06 US disclosed
US-9670476-B2 Enzyme substrate comprising a functional dye and associated technology and methods BIOTIUM, INC. (US) 2017-06-06 US disclosed
US-9670476-B2 Enzyme substrate comprising a functional dye and associated technology and methods BIOTIUM, INC. (US) 2017-06-06 US disclosed
US-20160237421-A9 ENZYME SUBSTRATE COMPRISING A FUNCTIONAL DYE AND ASSOCIATED TECHNOLOGY AND METHODS BIOTIUM, INC. (US) 2016-08-18 US disclosed
US-20160237421-A9 ENZYME SUBSTRATE COMPRISING A FUNCTIONAL DYE AND ASSOCIATED TECHNOLOGY AND METHODS BIOTIUM, INC. (US) 2016-08-18 US disclosed
US-20160237421-A9 ENZYME SUBSTRATE COMPRISING A FUNCTIONAL DYE AND ASSOCIATED TECHNOLOGY AND METHODS BIOTIUM, INC. (US) 2016-08-18 US disclosed
US-20140273151-A1 ENZYME SUBSTRATE COMPRISING A FUNCTIONAL DYE AND ASSOCIATED TECHNOLOGY AND METHODS BIOTIUM, INC. (US) 2014-09-18 US disclosed
US-20140273151-A1 ENZYME SUBSTRATE COMPRISING A FUNCTIONAL DYE AND ASSOCIATED TECHNOLOGY AND METHODS BIOTIUM, INC. (US) 2014-09-18 US disclosed
US-20140273151-A1 ENZYME SUBSTRATE COMPRISING A FUNCTIONAL DYE AND ASSOCIATED TECHNOLOGY AND METHODS BIOTIUM, INC. (US) 2014-09-18 US disclosed
US-8778627-B2 Enzyme substrate comprising a functional dye and associated technology and methods BIOTIUM, INC. (US) 2014-07-15 US disclosed
US-20120115129-A1 ENZYME SUBSTRATE COMPRISING A FUNCTIONAL DYE AND ASSOCIATED TECHNOLOGY AND METHODS BIOTIUM, INC. (US) 2012-05-10 US disclosed
US-20120115129-A1 ENZYME SUBSTRATE COMPRISING A FUNCTIONAL DYE AND ASSOCIATED TECHNOLOGY AND METHODS BIOTIUM, INC. (US) 2012-05-10 US disclosed
US-20120115129-A1 ENZYME SUBSTRATE COMPRISING A FUNCTIONAL DYE AND ASSOCIATED TECHNOLOGY AND METHODS BIOTIUM, INC. (US) 2012-05-10 US disclosed
US-8092784-B2 Enzyme substrate comprising a functional dye and associated technology and methods BIOTIUM, INC. (US) 2012-01-10 US disclosed
US-8092784-B2 Enzyme substrate comprising a functional dye and associated technology and methods BIOTIUM, INC. (US) 2012-01-10 US disclosed
US-8092784-B2 Enzyme substrate comprising a functional dye and associated technology and methods BIOTIUM, INC. (US) 2012-01-10 US disclosed
US-20090148386-A1 ENZYME SUBSTRATE COMPRISING A FUNCTIONAL DYE AND ASSOCIATED TECHNOLOGY AND METHODS BIOTIUM, INC. 2009-06-11 US disclosed
US-20090148386-A1 ENZYME SUBSTRATE COMPRISING A FUNCTIONAL DYE AND ASSOCIATED TECHNOLOGY AND METHODS BIOTIUM, INC. 2009-06-11 US disclosed
US-20090148386-A1 ENZYME SUBSTRATE COMPRISING A FUNCTIONAL DYE AND ASSOCIATED TECHNOLOGY AND METHODS BIOTIUM, INC. 2009-06-11 US disclosed
WO-2007100392-A2 ENZYME SUBSTRATE COMPRISING A FUNCTIONAL DYE AND ASSOCIATED TECHNOLOGY AND METHODS BIOTIUM, INC. (US) 2007-09-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120115129-A1 ENZYME SUBSTRATE COMPRISING A FUNCTIONAL DYE AND ASSOCIATED TECHNOLOGY AND METHODS ENGASE, GBA3, HSD17B14 DCTPP1 1863/4885TNF 3895/4885GALR3 3366/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.