Sugi Predict

Sugi Predict / Compounds / SCHEMBL317762

SCHEMBL317762

SCHEMBL317762

CCCCCC(CO)CC(=O)O

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 1/20 0.61
▸ GPR84 Q9NQS5 10/20 0.57
▸ ALDH1A1 P00352 3/20 0.50
▸ FFAR1 O14842 3/20 0.46
▸ FFAR4 Q5NUL3 2/20 0.46
▸ PPARD Q03181 5/20 0.44
▸ MAPT P10636 1/20 0.44
▸ LCK P06239 1/20 0.44
▸ ZDHHC20 Q5W0Z9 1/20 0.44
▸ ZDHHC2 Q9UIJ5 1/20 0.44
▸ AKR1B1 P15121 1/20 0.43
▸ PPARG P37231 4/20 0.41
▸ PPARA Q07869 4/20 0.41
▸ TSHR P16473 3/20 0.41
▸ HDAC11 Q96DB2 3/20 0.41
▸ TDP1 Q9NUW8 2/20 0.41
▸ SLC22A6 Q4U2R8 1/20 0.41
▸ SLC22A8 Q8TCC7 1/20 0.41
▸ TLR2 O60603 1/20 0.41
▸ MEN1 O00255 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1881443 0.98 LMNA (0.65) LMNAGPR84ALDH1A1FFAR1FFAR4
SCHEMBL27518246 0.98 LMNA (0.65) LMNAGPR84ALDH1A1FFAR1FFAR4
SCHEMBL27281307 0.98 LMNA (0.65) LMNAGPR84ALDH1A1FFAR1FFAR4
SCHEMBL27678299 0.98 LMNA (0.65) LMNAGPR84ALDH1A1FFAR1FFAR4
SCHEMBL27915359 0.98 LMNA (0.65) LMNAGPR84ALDH1A1FFAR1FFAR4
SCHEMBL27915361 0.98 LMNA (0.65) LMNAGPR84ALDH1A1FFAR1FFAR4
SCHEMBL10476357 0.98 LMNA (0.65) LMNAGPR84ALDH1A1FFAR1FFAR4
SCHEMBL4654033 0.98 LMNA (0.65) LMNAGPR84ALDH1A1FFAR1FFAR4
SCHEMBL5104868 0.94 ALDH1A1 (0.58) LMNAGPR84ALDH1A1FFAR1FFAR4
SCHEMBL5112958 0.94 ALDH1A1 (0.58) LMNAGPR84ALDH1A1FFAR1FFAR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105008403-B Water-insoluble cyclodextrin condensation polymer；Purposes as capturing agent 莱雅公司 2019-03-19 — — CN disclosed
US-8093278-B2 Substituted indoles ASTRAZENECA AB (SE) 2012-01-10 — — US disclosed
CN-1910168-B Alkyl carbamate substituted butyrolactones as lipase inhibitors SOLVAY PHARM BV 2011-03-30 — — CN disclosed
US-20100210685-A1 Novel Substituted Indoles ASTRAZENECA AB (SE) 2010-08-19 — — US disclosed
US-7754735-B2 Substituted indoles ASTRAZENECA AB (SE) 2010-07-13 — — US disclosed
EP-1113033-B1 Polyhydroxyalkanoate CANON KK (JP) 2008-11-26 — — EP disclosed
CN-1910168-A Alkyl carbamate substituted butyrolactones as lipase inhibitors SOLVAY PHARM GMBH (DE) 2007-02-07 — — CN disclosed
US-7169598-B2 Polyhydroxyalkanoate, method for production thereof and microorganisms for use in the same CANON KABUSHIKI KAISHA (JP) 2007-01-30 — — US disclosed
CN-1260266-C Poly(hydroxy alkanoate), its preparation method and use of microbe in its preparation CANON KK (JP) 2006-06-21 — — CN disclosed
US-20050222201-A1 such as 3-(2-chloro-4-quinolinyl)-2,5-dimethyl-1H-indole-1-acetic acid, used for treating respiratory system disorders and as inhibitors of G protein-coupled receptor chemoattractant homologous receptor expressed on lymphocyte cells (CRTH2) ASTRAZENECA AB (SE) 2005-10-06 — — US disclosed
US-20030208029-A1 Polyhydroxyalkanoate, method for production thereof and microorganisms for use in the same CANON KABUSHIKI KAISHA (JP) 2003-11-06 — — US disclosed
US-6586562-B2 Polylactone with units such as of 3-hydroxy-5-(4-fluorophenyl)valeric acid; biosynthesis of the polylactone by microorganism; Pseudomonas cichorii; P. putida; P. jessenii CANON KABUSHIKI KAISHA (JP) 2003-07-01 — — US disclosed
US-20020022253-A1 Polyhydroxyalkanoate, method for production thereof and microorganisms for use in the same CANON KABUSHIKI KAISHA (JP) 2002-02-21 — — US disclosed
CN-1321695-A Poly(hydroxy alkanoate), its preparation method and use of microbe in its preparation CANON KK (JP) 2001-11-14 — — CN disclosed
EP-1113033-A2 Polyhydroxyalkanoate, method for production thereof and microorganisms for use in the same CANON KABUSHIKI KAISHA (JP) 2001-07-04 — — EP disclosed
US-5414013-A Enzyme inhibitors E. R. SQUIBB & SONS, INC. (US) 1995-05-09 — — US disclosed
US-5374615-A Treating hypertension and congestive heart failure, preventing cardiac hypertrophy E. R. SQUIBB & SONS, INC. (US) 1994-12-20 — — US disclosed
EP-0449523-B1 Mercapto- or acylthio-trifluoromethyl amide derivatives and their use SQUIBB & SONS INC (US) 1994-08-17 — — EP disclosed
EP-0488532-A1 Indole- and benzimidazole-substituted imidazole and benzimidazole derivatives E.R. Squibb & Sons, Inc. (US) 1992-06-03 — — EP disclosed
EP-0449523-A1 Mercapto- or acylthio-trifluoromethyl amide derivatives and their use E.R. SQUIBB & SONS, INC. (US) 1991-10-02 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100210685-A1 Novel Substituted Indoles IDO1, IDO2, TPH1 LMNA 4170/4885GPR84 487/4885ALDH1A1 298/4885
US-20050222201-A1 such as 3-(2-chloro-4-quinolinyl)-2,5-dimethyl-1H-indole-1-acetic acid, used for treating respiratory system disorders and as inhibitors of G protein-coupled receptor chemoattractant homologous receptor expressed on lymphocyte cells (CRTH2) HRH2, HRH1, HCAR2 LMNA 4584/4885GPR84 50/4885ALDH1A1 533/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.