Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 1/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.41 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | STAT1 | P42224 | 1/20 | 0.39 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 3/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24670581 | 0.77 | GRM4 (0.48) | GRM4ABCG2ABCB1ABCC1ALDH1A1 | |
| SCHEMBL28385110 | 0.77 | GRM4 (0.48) | GRM4ABCG2ABCB1ABCC1ALDH1A1 | |
| SCHEMBL15476219 | 0.76 | GRM4 (0.47) | GRM4ABCG2ABCB1ABCC1ALDH1A1 | |
| SCHEMBL31276213 | 0.76 | GRM4 (0.47) | GRM4ABCG2ABCB1ABCC1ALDH1A1 | |
| SCHEMBL3177246 | 0.76 | CYP1A2 (0.45) | ALDH1A1MAPTCYP1A2CYP2C19TSHR | |
| SCHEMBL12555538 | 0.75 | GRM4 (0.47) | GRM4ABCG2ABCB1ABCC1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8202141 | 0.74 | GRM4 (0.46) | GRM4ABCG2ABCB1ABCC1ALDH1A1 | |
| SCHEMBL27261405 | 0.73 | ALDH1A1 (0.51) | GRM4ABCG2ABCB1ABCC1ALDH1A1 | |
| SCHEMBL30376409 | 0.72 | AR (0.51) | ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL364484 | 0.72 | AR (0.51) | ALDH1A1MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7652062-B2 | Cyanopyrrole-phenyl amide progesterone receptor modulators and uses thereof | WYETH LLC (US) | 2010-01-26 | — | — | US | disclosed |
| CN-101287461-A | Use of 5-amido-1h-pyrrole-2-nitrile derivative as progesterone receptor modulators | WYETH CORP (US) | 2008-10-15 | — | — | CN | disclosed |
| EP-1909785-A2 | USE OF PROGESTERONE RECEPTOR MODULATORS | Wyeth a Corporation of the State of Delaware (US) | 2008-04-16 | — | — | EP | disclosed |
| EP-1910284-A1 | CYANOPYRROLE-PHENYL AMIDE PROGESTERONE RECEPTOR MODULATORS AND USES THEREOF | Wyeth (US) | 2008-04-16 | — | — | EP | disclosed |
| US-20080064673-A1 | Cyanopyrrole-phenyl amide progesterone receptor modulators and uses thereof | WYETH (US) | 2008-03-13 | — | — | US | disclosed |
| US-7297713-B2 | Cyanopyrrole-phenyl amide progesterone receptor modulators and uses thereof | WYETH (US) | 2007-11-20 | — | — | US | disclosed |
| WO-2007016211-A1 | CYANOPYRROLE-PHENYL AMIDE PROGESTERONE RECEPTOR MODULATORS AND USES THEREOF | WYETH (US) | 2007-02-08 | — | — | WO | disclosed |
| WO-2007016385-A2 | USE OF SUBSTITUTED 5-AMINO-1H-PYRROLE-2-CARBONITRILE DERIVATIVES AS PROGESTERONE RECEPTOR MODULATORS | WYETH (US) | 2007-02-08 | — | — | WO | disclosed |
| US-20070027201-A1 | Use of progesterone receptor modulators | WYETH (US) | 2007-02-01 | — | — | US | disclosed |
| US-20070027125-A1 | Cyanopyrrole-phenyl progesterone receptor modulators and uses thereof | WYETH (US) | 2007-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080064673-A1 | Cyanopyrrole-phenyl amide progesterone receptor modulators and uses thereof | PGR, GNRHR, PGRMC1 | GRM4 854/4885ABCG2 1992/4885ABCB1 1214/4885 |
| US-20070027125-A1 | Cyanopyrrole-phenyl progesterone receptor modulators and uses thereof | PGR, PGRMC1, PGRMC2 | GRM4 832/4885ABCG2 1947/4885ABCB1 845/4885 |
| US-20070027201-A1 | Use of progesterone receptor modulators | GNRHR, PGR, FSHR | GRM4 396/4885ABCG2 4515/4885ABCB1 3257/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.