Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 6/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | HTT | P42858 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TNF | P01375 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8078272 | 0.90 | CYP11B1 (0.52) | CYP11B1CYP11B2SMN1; SMN2HTTLMNA | |
| SCHEMBL3497848 | 0.86 | CYP11B1 (0.60) | CYP11B1CYP11B2SMN1; SMN2HTTLMNA | |
| SCHEMBL9302833 | 0.80 | SMN1; SMN2 (0.73) | CYP11B1CYP11B2SMN1; SMN2HTTLMNA | |
| SCHEMBL3497173 | 0.79 | RECQL (0.46) | SMN1; SMN2LMNARECQLTSHRKMT2A | |
| SCHEMBL3178904 | 0.77 | HDAC1 (0.46) | HDAC1HDAC6 | |
| SCHEMBL3496132 | 0.77 | CYP11B1 (0.59) | CYP11B1CYP11B2SMN1; SMN2HTTLMNA | |
| SCHEMBL2792417 | 0.77 | ALDH1A1 (0.59) | SMN1; SMN2LMNANPSR1HDAC1HDAC6 | |
| SCHEMBL3185603 | 0.76 | HDAC1 (0.47) | HDAC1HDAC6ALDH1A1 | |
| SCHEMBL3496693 | 0.76 | CYP11B1 (0.60) | CYP11B1CYP11B2SMN1; SMN2HTTLMNA | |
| SCHEMBL3498617 | 0.76 | CYP11B1 (0.54) | CYP11B1CYP11B2SMN1; SMN2HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803825-B2 | Aminoalkylazole derivatives as histamine-3 antagonists | WYETH LLC (US) | 2010-09-28 | — | — | US | disclosed |
| US-7803825-B2 | Aminoalkylazole derivatives as histamine-3 antagonists | WYETH LLC (US) | 2010-09-28 | — | — | US | disclosed |
| US-7803825-B2 | Aminoalkylazole derivatives as histamine-3 antagonists | WYETH LLC (US) | 2010-09-28 | — | — | US | disclosed |
| EP-2170875-A1 | AMINOALKYLAZOLE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | Wyeth LLC (US) | 2010-04-07 | — | — | EP | disclosed |
| WO-2010009029-A2 | METHODS FOR THE PREPARATION OF AZOLE COMPOUNDS | WYETH (US) | 2010-01-21 | — | — | WO | disclosed |
| WO-2010009029-A2 | METHODS FOR THE PREPARATION OF AZOLE COMPOUNDS | WYETH (US) | 2010-01-21 | — | — | WO | disclosed |
| US-20100016609-A1 | METHODS FOR THE PREPARATION OF AZOLE COMPOUNDS | WYETH (US) | 2010-01-21 | — | — | US | disclosed |
| US-20100016609-A1 | METHODS FOR THE PREPARATION OF AZOLE COMPOUNDS | WYETH (US) | 2010-01-21 | — | — | US | disclosed |
| US-20100016609-A1 | METHODS FOR THE PREPARATION OF AZOLE COMPOUNDS | WYETH (US) | 2010-01-21 | — | — | US | disclosed |
| US-20090023707-A1 | AMINOALKYLAZOLE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2009-01-22 | — | — | US | disclosed |
| US-20090023707-A1 | AMINOALKYLAZOLE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2009-01-22 | — | — | US | disclosed |
| WO-2009012252-A1 | AMINOALKYLAZOLE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2009-01-22 | — | — | WO | disclosed |
| US-20090023707-A1 | AMINOALKYLAZOLE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2009-01-22 | — | — | US | disclosed |
| WO-2009012252-A1 | AMINOALKYLAZOLE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2009-01-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023707-A1 | AMINOALKYLAZOLE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | HRH4, HRH3, HRH2 | CYP11B1 2926/4885CYP11B2 2281/4885SMN1; SMN2 2240/4885 |
| US-20100016609-A1 | METHODS FOR THE PREPARATION OF AZOLE COMPOUNDS | CYP3A5, CYP3A7, CYP11B1 | CYP11B1 3/4885CYP11B2 5/4885SMN1; SMN2 4843/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.