Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.36 |
| ▸ | TGM2 | P21980 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 3/20 | 0.31 |
| ▸ | DRD5 | P21918 | 3/20 | 0.31 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | TACR2 | P21452 | 1/20 | 0.31 |
| ▸ | TACR3 | P29371 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3178920 | 1.00 | KDM4E (0.36) | KDM4ENPSR1PDE4BPDE7ATGM2 | |
| SCHEMBL3175361 | 0.91 | POLB (0.39) | PDE4BPDE7ASMN1; SMN2GRM1DRD1 | |
| SCHEMBL3175372 | 0.91 | POLB (0.39) | PDE4BPDE7ASMN1; SMN2GRM1DRD1 | |
| SCHEMBL3169324 | 0.85 | PDE4B (0.33) | PDE4BPDE7ASMN1; SMN2 | |
| SCHEMBL3169334 | 0.85 | PDE4B (0.33) | PDE4BPDE7ASMN1; SMN2 | |
| SCHEMBL13660351 | 0.78 | SMN1; SMN2 (0.34) | PDE4BPDE7ASMN1; SMN2GRM1POLB | |
| SCHEMBL13532363 | 0.76 | HSD17B10 (0.37) | NPSR1TSHRDRD1DRD5SCN9A | |
| SCHEMBL4755656 | 0.75 | MEN1 (0.39) | KDM4ESMN1; SMN2AOC3POLBSCN9A | |
| SCHEMBL4755659 | 0.75 | MEN1 (0.39) | KDM4ESMN1; SMN2AOC3POLBSCN9A | |
| SCHEMBL3178194 | 0.74 | DRD1 (0.38) | SMN1; SMN2DRD1DRD5AOC3SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100008866-A1 | CIS-CYCLOHEXYL SUBSTITUTED PYRIMIDINONE DERIVATIVES | NEUROGEN CORPORATION (US) | 2010-01-14 | — | — | US | claimed |
| EP-2094704-A2 | CIS-CYCLOHEXYL SUBSTITUTED PYRIMIDINONE DERIVATIVES | Neurogen Corporation (US) | 2009-09-02 | — | — | EP | claimed |
| WO-2008066664-A2 | CIS-CYCLOHEXYL SUBSTITUTED PYRIMIDINONE DERIVATIVES | NEUROGEN CORPORATION (US) | 2008-06-05 | — | — | WO | claimed |
| US-20100008866-A1 | CIS-CYCLOHEXYL SUBSTITUTED PYRIMIDINONE DERIVATIVES | NEUROGEN CORPORATION (US) | 2010-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100008866-A1 | CIS-CYCLOHEXYL SUBSTITUTED PYRIMIDINONE DERIVATIVES | PIGS, GPR174, GPR17 | KDM4E 3610/4885NPSR1 88/4885PDE4B 1345/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.