SCHEMBL318464

SCHEMBL318464

N#Cc1cc(CNC=O)ccc1F

nearest known ligand 0.43

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ADH1B P00325 1/20 0.42
ADH1C P00326 1/20 0.42
ADH1A P07327 1/20 0.42
ADH7 P40394 1/20 0.42
VNN1 O95497 1/20 0.38
DPP4 P27487 2/20 0.37
DPP8 Q6V1X1 1/20 0.37
AR P10275 1/20 0.37
TRPV4 Q9HBA0 2/20 0.36
GRM4 Q14833 1/20 0.35
CACNA1H O95180 2/20 0.35
PTP4A3 O75365 1/20 0.35
ALOX5 P09917 1/20 0.34
CHRNA7 P36544 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL51841 0.84 TRPV4 (0.41) VNN1DPP4DPP8ARTRPV4
SCHEMBL2975866 0.80 TRPV4 (0.40) VNN1DPP4DPP8ARTRPV4
SCHEMBL25488907 0.80 LOXL2 (0.50) VNN1DPP4DPP8ARTRPV4
SCHEMBL3304771 0.79 ADH1B (0.50) ADH1BADH1CADH1AADH7
Hydrochloric Acid SCHEMBL28803208 0.77 MAPT (0.40) VNN1DPP4DPP8ARTRPV4
SCHEMBL15018389 0.75 TRPV4 (0.42) VNN1DPP4DPP8ARTRPV4
SCHEMBL3359490 0.75 CYP2C9 (0.50) VNN1DPP4DPP8GRM4CACNA1H
SCHEMBL24872544 0.75 TRPV4 (0.45) VNN1DPP4DPP8ARTRPV4
SCHEMBL3304927 0.75 HDAC3 (0.49) ADH1BADH1CADH1AADH7
SCHEMBL3311011 0.75 HDAC3 (0.46) ADH1BADH1CADH1AADH7GRM4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012004326-A1 PESTICIDAL PYRROLINE DERIVATIVES BAYER CROPSCIENCE AG (DE) 2012-01-12 WO disclosed
WO-2012004326-A1 PESTICIDAL PYRROLINE DERIVATIVES BAYER CROPSCIENCE AG (DE) 2012-01-12 WO disclosed