Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 6/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26670550 | 0.75 | METAP2 (0.33) | — | |
| SCHEMBL23388889 | 0.71 | GRIN1 (0.34) | CCR2GRIN1GRIN2APOLB | |
| SCHEMBL6730153 | 0.67 | GRIN1 (0.38) | GRIN1GRIN2APOLB | |
| SCHEMBL17163848 | 0.67 | HPGDS (0.41) | — | |
| SCHEMBL6608975 | 0.67 | HPGDS (0.41) | — | |
| SCHEMBL23388812 | 0.67 | POLB (0.46) | POLB | |
| SCHEMBL26670525 | 0.66 | — | — | |
| SCHEMBL6731661 | 0.66 | TSHR (0.45) | CCR2GRIN1GRIN2APOLB | |
| SCHEMBL25134720 | 0.66 | TSHR (0.45) | CCR2GRIN1GRIN2APOLB | |
| SCHEMBL2077753 | 0.66 | GRIN1 (0.37) | GRIN1GRIN2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2585447-A2 | COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS | Vertex Pharmaceuticals Incorporated (US) | 2013-05-01 | — | — | EP | disclosed |
| WO-2012006055-A2 | COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-01-12 | — | — | WO | disclosed |