Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2218400 | 0.66 | HSD17B10 (0.63) | HSD17B10CYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL29625706 | 0.65 | CYP1A2 (0.71) | HSD17B10CYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL23515386 | 0.65 | CYP1A2 (0.71) | HSD17B10CYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL21438254 | 0.65 | KDM4E (0.66) | HSD17B10CYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL30019941 | 0.64 | HSD17B10 (0.51) | HSD17B10CYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL3361843 | 0.64 | HSD17B10 (0.70) | HSD17B10CYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL226196 | 0.63 | HSD17B10 (0.76) | HSD17B10CYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL36762 | 0.63 | HSD17B10 (1.00) | HSD17B10CYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL29357214 | 0.63 | HSD17B10 (1.00) | HSD17B10CYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL3272925 | 0.62 | HSD17B10 (0.68) | HSD17B10CYP1A2CYP2C9CYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7666904-B2 | 3-aryl-4-hydroxyfuranone compounds and the human and animal health use thereof | WYETH LLC (US) | 2010-02-23 | — | — | US | disclosed |
| US-7495027-B2 | 3-aryl-4-hydroxyfuranone compounds and the human and animal health use thereof | WYETH (US) | 2009-02-24 | — | — | US | disclosed |
| US-20090036439-A1 | 3-ARYL-4-HYDROXYFURANONE COMPOUNDS AND THE HUMAN AND ANIMAL HEALTH USE THEREOF | WYETH (US) | 2009-02-05 | — | — | US | disclosed |
| US-20050054721-A1 | 3-Aryl-4-Hydroxyfuranone compounds and the human and animal health use thereof | WYETH (US) | 2005-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054721-A1 | 3-Aryl-4-Hydroxyfuranone compounds and the human and animal health use thereof | FUCA1, PGLS, HSD17B14 | HSD17B10 214/4885CYP1A2 509/4885CYP2C9 604/4885 |
| US-20090036439-A1 | 3-ARYL-4-HYDROXYFURANONE COMPOUNDS AND THE HUMAN AND ANIMAL HEALTH USE THEREOF | FUCA1, PGLS, HSD17B14 | HSD17B10 214/4885CYP1A2 509/4885CYP2C9 604/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.