Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | THPO | P40225 | 1/20 | 0.34 |
| ▸ | VCP | P55072 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL487465 | 0.85 | MAPT (0.56) | MAPTAPPNPSR1ASIC3NPC1 | |
| SCHEMBL18561130 | 0.81 | MAPT (0.53) | MAPTAPPASIC3HTTKCNH2 | |
| Bicarbonate SCHEMBL28540490 | 0.79 | MAPT (0.51) | MAPTAPPNPSR1ASIC3NPC1 | |
| Dimethylamine SCHEMBL700542 | 0.79 | MAPT (0.51) | MAPTAPPNPSR1ASIC3NPC1 | |
| SCHEMBL9460554 | 0.77 | LMNA (0.54) | MAPTAPPNPC1RAB9AKCNH2 | |
| SCHEMBL17312253 | 0.76 | APP (0.73) | MAPTAPPNPSR1NPC1MTOR | |
| SCHEMBL30495998 | 0.76 | APP (0.73) | MAPTAPPNPSR1NPC1MTOR | |
| SCHEMBL403663 | 0.76 | APP (0.73) | MAPTAPPNPSR1NPC1MTOR | |
| Benzene SCHEMBL28733255 | 0.76 | APP (0.73) | MAPTAPPNPSR1NPC1MTOR | |
| SCHEMBL9460884 | 0.76 | LMNA (0.46) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7667040-B2 | Azacyclic ethynyl derivatives | NEUROSEARCH A/S (DK) | 2010-02-23 | — | — | US | disclosed |
| US-20080188519-A1 | Novel azacyclic ethynyl derivatives | ANIONA APS (DK) | 2008-08-07 | — | — | US | disclosed |
| EP-1506205-B1 | NOVEL AZACYCLIC ETHYNYL DERIVATIVES | NEUROSEARCH AS (DK) | 2008-07-16 | — | — | EP | disclosed |
| US-7378526-B2 | Azacyclic ethynyl derivatives | NEUROSEARCH A/S (DK) | 2008-05-27 | — | — | US | disclosed |
| US-20050171078-A1 | Novel azacyclic ethynyl derivatives | NEUROSEARCH (DK) | 2005-08-04 | — | — | US | disclosed |
| EP-1506205-A2 | NOVEL AZACYCLIC ETHYNYL DERIVATIVES | NEUROSEARCH A/S (DK) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003094830-A2 | NOVEL AZACYCLIC ETHYNYL DERIVATIVES | NEUROSEARCH A/S (DK) | 2003-11-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050171078-A1 | Novel azacyclic ethynyl derivatives | CHRNA6, CHRNA5, CHRNA10 | MAPT 1207/4885APP 3548/4885NPSR1 70/4885 |
| US-20080188519-A1 | Novel azacyclic ethynyl derivatives | CHRNA6, CHRNA10, CHRNA5 | MAPT 1028/4885APP 3483/4885NPSR1 63/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.