Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 13/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.31 |
| ▸ | GPR183 | P32249 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | IKBKB | O14920 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL834806 | 0.87 | MET (0.41) | METMEN1NPC1RAB9AKMT2A | |
| SCHEMBL837600 | 0.74 | KDM4E (0.44) | NPC1RAB9ADYRK1ATGFBR1 | |
| SCHEMBL838631 | 0.72 | HPGD (0.38) | MEN1NPC1RAB9AKMT2ADYRK1A | |
| SCHEMBL836888 | 0.69 | MET (0.60) | MET | |
| SCHEMBL838283 | 0.68 | MET (0.57) | MET | |
| SCHEMBL838248 | 0.67 | CYP11B2 (0.35) | MEN1NPC1RAB9AKMT2ADYRK1A | |
| SCHEMBL837156 | 0.66 | CYP11B2 (0.37) | NPC1RAB9ADYRK1ATGFBR1IKBKB | |
| SCHEMBL837789 | 0.66 | MET (0.47) | METMEN1NPC1RAB9AKMT2A | |
| SCHEMBL14127237 | 0.65 | NPC1 (0.54) | MEN1NPC1RAB9AKMT2ADYRK1A | |
| SCHEMBL10543 | 0.65 | NPC1 (0.54) | MEN1NPC1RAB9AKMT2ADYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7683060-B2 | Triazolotriazines as kinase inhibitors | INCYTE CORPORATION (US) | 2010-03-23 | — | — | US | claimed |