Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 3/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.38 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.33 |
| ▸ | LIPE | Q05469 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.32 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.32 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27975881 | 0.82 | DPP4 (0.39) | DPP4DPP8DPP9ALDH1A1DPP7 | |
| SCHEMBL30600057 | 0.78 | DPP4 (0.41) | DPP4DPP8DPP9MEN1KMT2A | |
| SCHEMBL1133814 | 0.76 | — | — | |
| SCHEMBL29299508 | 0.76 | SLC6A9 (0.40) | MEN1KMT2AALDH1A1TP53SLC6A9 | |
| SCHEMBL1165366 | 0.76 | SLC6A9 (0.40) | MEN1KMT2AALDH1A1TP53SLC6A9 | |
| SCHEMBL24220960 | 0.76 | SLC6A9 (0.40) | MEN1KMT2AALDH1A1TP53SLC6A9 | |
| SCHEMBL3967181 | 0.76 | SLC6A9 (0.40) | MEN1KMT2AALDH1A1TP53SLC6A9 | |
| SCHEMBL7744888 | 0.76 | SLC6A9 (0.40) | MEN1KMT2AALDH1A1TP53SLC6A9 | |
| SCHEMBL14100030 | 0.76 | SLC6A9 (0.40) | MEN1KMT2AALDH1A1TP53SLC6A9 | |
| SCHEMBL13223389 | 0.76 | SLC6A9 (0.40) | MEN1KMT2AALDH1A1TP53SLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029536-B1 | BICYCLIC TETRAHYDROPYRROLE COMPOUNDS | ESTEVE LABOR DR (ES) | 2013-08-28 | — | — | EP | disclosed |
| US-8299113-B2 | Bicyclic tetrahydropyrrole compounds | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2012-10-30 | — | — | US | disclosed |
| US-20100029738-A1 | Bicyclic Tetrahydropyrrole Compounds | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2010-02-04 | — | — | US | disclosed |
| EP-2029536-A1 | BICYCLIC TETRAHYDROPYRROLE COMPOUNDS | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007128458-A1 | BICYCLIC TETRAHYDROPYRROLE COMPOUNDS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2007-11-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029738-A1 | Bicyclic Tetrahydropyrrole Compounds | CYP11B2, CYP11B1, SDHA | DPP4 2838/4885DPP8 3046/4885DPP9 3774/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.