Sugi Predict

Sugi Predict / Compounds / SCHEMBL3194076

SCHEMBL3194076

SCHEMBL3194076

COc1ccoc1C(=O)N(c1ccccc1)c1nccs1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 2/20 0.43
▸ TSHR P16473 2/20 0.41
▸ GAA P10253 1/20 0.41
▸ MEN1 O00255 2/20 0.39
▸ KMT2A Q03164 2/20 0.39
▸ HIF1A Q16665 1/20 0.39
▸ FFAR1 O14842 1/20 0.36
▸ FFAR4 Q5NUL3 1/20 0.36
▸ ECE1 P42892 1/20 0.36
▸ NPC1 O15118 2/20 0.35
▸ RAB9A P51151 2/20 0.35
▸ QPCT Q16769 1/20 0.35
▸ KDM4E B2RXH2 3/20 0.35
▸ HPGD P15428 2/20 0.35
▸ USP2 O75604 1/20 0.35
▸ ALDH1A1 P00352 1/20 0.35
▸ ADRB2 P07550 1/20 0.35
▸ CTSA P10619 2/20 0.35
▸ RORC P51449 1/20 0.35
▸ RORB Q92753 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3201018 0.81 NPC1 (0.46) LMNATSHRGAAMEN1KMT2A
SCHEMBL3201982 0.77 TRPM8 (0.45) LMNATSHRGAAMEN1KMT2A
SCHEMBL27930079 0.75 LMNA (0.50) LMNATSHRGAAMEN1KMT2A
SCHEMBL2772989 0.73 LMNA (0.51) LMNATSHRMEN1KMT2AFFAR1
SCHEMBL1896858 0.73 LMNA (0.53) LMNAMEN1KMT2AFFAR1FFAR4
SCHEMBL2772986 0.70 LMNA (0.51) LMNAMEN1KMT2AFFAR1FFAR4
SCHEMBL1325354 0.70 LMNA (0.51) LMNAGAAMEN1KMT2AFFAR1
SCHEMBL28977221 0.70 LMNA (0.48) LMNAMEN1KMT2AFFAR1FFAR4
SCHEMBL17439454 0.70 LMNA (0.48) LMNAMEN1KMT2AFFAR1FFAR4
SCHEMBL1458950 0.70 LMNA (0.57) LMNAMEN1KMT2AFFAR1FFAR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7795290-B2 2-amido-thiazole-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof GENENTECH, INC. (US) 2010-09-14 — — US disclosed
US-20090048313-A1 2-AMIDO-THIAZOLE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF GENENTECH, INC. (US) 2009-02-19 — — US disclosed
US-7410988-B2 2-Amido-thiazole-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof GENENTECH, INC. (US) 2008-08-12 — — US disclosed
US-20060052416-A1 2-Amido-thiazole-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof SQUARE 1 BANK 2006-03-09 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090048313-A1 2-AMIDO-THIAZOLE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF ATP5ME, ATP5MG, ATP5MK LMNA 4104/4885TSHR 2723/4885GAA 59/4885
US-20060052416-A1 2-Amido-thiazole-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof ATP5ME, ATP5MG, ATP5MK LMNA 4104/4885TSHR 2723/4885GAA 59/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.