Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | GABRP | O00591 | 3/20 | 0.42 |
| ▸ | GABRD | O14764 | 3/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.42 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.42 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.42 |
| ▸ | GABRE | P78334 | 3/20 | 0.42 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.42 |
| ▸ | GABRG1 | Q8N1C3 | 3/20 | 0.42 |
| ▸ | GABRG3 | Q99928 | 3/20 | 0.42 |
| ▸ | GABRQ | Q9UN88 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7840908 | 0.80 | LMNA (0.42) | KDM4EKMT2AHPGDGABRPGABRD | |
| SCHEMBL2693535 | 0.80 | AKR1C2 (0.39) | KDM4EKMT2AHPGDGABRPGABRD | |
| SCHEMBL14818690 | 0.77 | KDM4E (0.36) | KDM4EKMT2AHPGDALDH1A1HSD17B10 | |
| SCHEMBL11724124 | 0.77 | KDM4E (0.53) | KDM4EKMT2AHPGDGABRPGABRD | |
| SCHEMBL10200721 | 0.77 | KDM4E (0.49) | KDM4EKMT2AHPGDGABRPGABRD | |
| SCHEMBL2186263 | 0.77 | KDM4E (0.49) | KDM4EKMT2AHPGDGABRPGABRD | |
| SCHEMBL2483707 | 0.77 | KDM4E (0.49) | KDM4EKMT2AHPGDGABRPGABRD | |
| SCHEMBL3980791 | 0.74 | GABRP (0.43) | KDM4EKMT2AHPGDGABRPGABRD | |
| SCHEMBL29781361 | 0.74 | GABRP (0.43) | KDM4EKMT2AHPGDGABRPGABRD | |
| SCHEMBL11562679 | 0.74 | KDM4E (0.65) | KDM4EKMT2AHPGDGABRPGABRD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402349-B1 | TRICYCLIC PYRAZOLOPYRIMIDINE DERIVATIVES | DAIICHI SANKYO CO LTD (JP) | 2016-04-06 | — | — | EP | disclosed |
| US-20140371249-A1 | CRYSTAL OF A FREE TRICYCLIC PYRAZOLOPYRIMIDINE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-12-18 | — | — | US | disclosed |
| US-20140371249-A1 | CRYSTAL OF A FREE TRICYCLIC PYRAZOLOPYRIMIDINE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-12-18 | — | — | US | disclosed |
| US-20140371249-A1 | CRYSTAL OF A FREE TRICYCLIC PYRAZOLOPYRIMIDINE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-12-18 | — | — | US | disclosed |
| EP-2810945-A1 | Dihydrochloride salt of a tricyclic pyrazolopyrimidine derivative | Daiichi Sankyo Company, Limited (JP) | 2014-12-10 | — | — | EP | disclosed |
| US-8846703-B2 | Crystal of a free tricyclic pyrazolopyrimidine derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-09-30 | — | — | US | disclosed |
| US-8846703-B2 | Crystal of a free tricyclic pyrazolopyrimidine derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-09-30 | — | — | US | disclosed |
| US-8846703-B2 | Crystal of a free tricyclic pyrazolopyrimidine derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-09-30 | — | — | US | disclosed |
| US-8815880-B2 | Crystal of tricyclic pyrazolopyrimidine derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-08-26 | — | — | US | disclosed |
| US-8815880-B2 | Crystal of tricyclic pyrazolopyrimidine derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-08-26 | — | — | US | disclosed |
| US-8236813-B2 | Tricyclic pyrazolopyrimidine derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-08-07 | — | — | US | disclosed |
| US-8236813-B2 | Tricyclic pyrazolopyrimidine derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-08-07 | — | — | US | disclosed |
| WO-2012026433-A1 | FREE CRYSTAL OF TRICYCLIC PYRAZOLOPYRIMIDINE DERIVATIVE | 第一三共株式会社 (JP) | 2012-03-01 | — | — | WO | disclosed |
| WO-2012026434-A1 | CRYSTAL OF TRICYCLIC PYRAZOLOPYRIMIDINE DERIVATIVE | 第一三共株式会社 (JP) | 2012-03-01 | — | — | WO | disclosed |
| CN-102333781-A | Tricyclic pyrazolopyrimidine derivatives | DAIICHI SANKYO CO LTD | 2012-01-25 | — | — | CN | disclosed |
| EP-2402349-A1 | TRICYCLIC PYRAZOLOPYRIMIDINE DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2012-01-04 | — | — | EP | disclosed |
| US-20110071170-A1 | TRICYCLIC PYRAZOLOPYRIMIDINE DERIVATIVES | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2011-03-24 | — | — | US | disclosed |
| US-20110071170-A1 | TRICYCLIC PYRAZOLOPYRIMIDINE DERIVATIVES | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2011-03-24 | — | — | US | disclosed |
| US-20110071170-A1 | TRICYCLIC PYRAZOLOPYRIMIDINE DERIVATIVES | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2011-03-24 | — | — | US | disclosed |
| WO-2010098344-A1 | TRICYCLIC PYRAZOLOPYRIMIDINE DERIVATIVE | 第一三共株式会社 (JP) | 2010-09-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140371249-A1 | CRYSTAL OF A FREE TRICYCLIC PYRAZOLOPYRIMIDINE DERIVATIVE | HSP90AB2P, HSP90B1, HSP90AA1 | KDM4E 1799/4885KMT2A 1965/4885HPGD 2107/4885 |
| US-20110071170-A1 | TRICYCLIC PYRAZOLOPYRIMIDINE DERIVATIVES | HSP90AB1, HSP90B1, HSP90AA1 | KDM4E 3698/4885KMT2A 4175/4885HPGD 1053/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.