Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.39 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.39 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | GABRP | O00591 | 2/20 | 0.36 |
| ▸ | GABRD | O14764 | 2/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2693535 | 0.83 | AKR1C2 (0.39) | LMNASMN1; SMN2AKR1C2AKR1C1AKR1C4 | |
| SCHEMBL3974375 | 0.83 | SMN1; SMN2 (0.45) | LMNASMN1; SMN2KEAP1NFE2L2HAVCR2 | |
| SCHEMBL31974 | 0.80 | KDM4E (0.49) | LMNASMN1; SMN2AKR1C2AKR1C1AKR1C4 | |
| SCHEMBL27716685 | 0.78 | HAVCR2 (0.50) | LMNASMN1; SMN2KEAP1NFE2L2HAVCR2 | |
| SCHEMBL3098275 | 0.78 | GABRP (0.43) | LMNASMN1; SMN2KEAP1NFE2L2HAVCR2 | |
| SCHEMBL391794 | 0.73 | KEAP1 (0.44) | LMNASMN1; SMN2KEAP1NFE2L2HAVCR2 | |
| SCHEMBL3980791 | 0.73 | GABRP (0.43) | LMNASMN1; SMN2KEAP1NFE2L2HAVCR2 | |
| SCHEMBL27407014 | 0.73 | LMNA (0.41) | LMNASMN1; SMN2KEAP1NFE2L2HAVCR2 | |
| SCHEMBL29781361 | 0.73 | GABRP (0.43) | LMNASMN1; SMN2KEAP1NFE2L2HAVCR2 | |
| SCHEMBL29418647 | 0.73 | KEAP1 (0.44) | LMNASMN1; SMN2KEAP1NFE2L2HAVCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0726270-B1 | Derivatives of 1,6-naphthyridone carboxylic acids | BAYER AG (DE) | 2001-05-23 | — | — | EP | disclosed |
| US-5811433-A | ANTIMICROBIALS | BAYER AKTIENGESELLSCHAFT (DE) | 1998-09-22 | — | — | US | disclosed |
| EP-0726270-A1 | Derivatives of 1,6-naphthyridine carboxylic acids | BAYER AG (DE) | 1996-08-14 | — | — | EP | disclosed |