Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.63 |
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9726746 | 1.00 | MAPT (0.63) | MAPTGPR139ALDH1A1HPGDMEN1 | |
| SCHEMBL1978152 | 1.00 | MAPT (0.63) | MAPTGPR139ALDH1A1HPGDMEN1 | |
| SCHEMBL9936127 | 0.85 | MAPT (0.63) | MAPTGPR139ALDH1A1HPGDMEN1 | |
| SCHEMBL5672188 | 0.84 | MAPT (0.61) | MAPTGPR139ALDH1A1HPGDMEN1 | |
| SCHEMBL12975495 | 0.83 | MAPT (0.65) | MAPTGPR139ALDH1A1HPGDMEN1 | |
| SCHEMBL7204764 | 0.83 | MAPT (0.65) | MAPTGPR139ALDH1A1HPGDMEN1 | |
| SCHEMBL28845306 | 0.83 | TSHR (0.64) | MAPTALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL6083488 | 0.83 | GPR139 (0.66) | MAPTGPR139ALDH1A1HPGDMEN1 | |
| SCHEMBL19285674 | 0.83 | GPR139 (0.66) | MAPTGPR139ALDH1A1HPGDMEN1 | |
| SCHEMBL12975787 | 0.83 | MAPT (0.65) | MAPTGPR139ALDH1A1HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048141-B1 | OPTICALLY PURE DIHYDROPYRIMIDINE COMPOUNDS AND THEIR USES FOR THE PREPARATION OF A MEDICAMENT FOR TREATMENT AND PREVENTION OF VIRAL DISEASES. | BEIJING MOLECULE SCIENCE AND TECH CO LTD (CN) | 2017-06-14 | — | — | EP | disclosed |
| US-8329902-B2 | Optically pure dihydropyrimidine compounds and their uses for the preparation of a medicament for treatment and prevention of viral diseases | BEIJING MOLECULE SCIENCE AND TECHNOLOGY CO., LTD. (CN) | 2012-12-11 | — | — | US | disclosed |
| US-8329902-B2 | Optically pure dihydropyrimidine compounds and their uses for the preparation of a medicament for treatment and prevention of viral diseases | BEIJING MOLECULE SCIENCE AND TECHNOLOGY CO., LTD. (CN) | 2012-12-11 | — | — | US | disclosed |
| CN-101104617-B | Dihydropyrimidine compounds and use of the same in preparing medicament for curing and preventing virosis | BEIJING MOLIK SCIENCE & TECHNOLOGY CO LTD | 2010-06-23 | — | — | CN | disclosed |
| US-RE41149-E1 | Stereoisomerically pure 7-[(7S)-7-amino-5-azaspiro[2.4]heptan-5-yl]-6-fluoro-1-[(1R,2S)-2-fluoro-1-cyclopropyl]-8-methoxy-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid or a pharmaceutically acceptable salt thereof; antibacterial agents | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2010-02-23 | — | — | US | disclosed |
| US-20100004268-A1 | Optically Pure Dihydropyrimidine Compounds and Their Uses for the Preparation of a Medicament for Treatment and Prevention of Viral Diseases | BEIJING MOLECULE SCIENCE AND TECHNOLOGY CO., LTD. (CN) | 2010-01-07 | — | — | US | disclosed |
| US-20100004268-A1 | Optically Pure Dihydropyrimidine Compounds and Their Uses for the Preparation of a Medicament for Treatment and Prevention of Viral Diseases | BEIJING MOLECULE SCIENCE AND TECHNOLOGY CO., LTD. (CN) | 2010-01-07 | — | — | US | disclosed |
| EP-2048141-A1 | OPTICAL PURE DIHYDROPYRIMIDINE COMPOUNDS, THEIR USES IN THE MANUFACTURE OF A MEDICAMNENT FOR THE TREATMENT OR THE PREVENTION OF VIROSIS DISEASES | Beijing Molecule Science and Technology Co., Ltd. (CN) | 2009-04-15 | — | — | EP | disclosed |
| CN-101104617-A | Dihydropyrimidine compounds and use for the same in preparing medicament for curing and preventing virosis | BEIJING MOLIK SCIENCE & TECHNO (CN) | 2008-01-16 | — | — | CN | disclosed |
| US-6031102-A | Optically active pyridonecarboxylic acid derivatives | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2000-02-29 | — | — | US | disclosed |
| US-5767127-A | BACTERICIDES | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1998-06-16 | — | — | US | disclosed |
| EP-0488227-B1 | Optically active pyridobenzoxazine derivatives | DAIICHI SEIYAKU CO (JP) | 1997-02-26 | — | — | EP | disclosed |
| US-5587386-A | BACTERICIDES, MICROBIOCIDES | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1996-12-24 | — | — | US | disclosed |
| US-5463053-A | Antimicrobial compounds | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1995-10-31 | — | — | US | disclosed |
| EP-0488227-A2 | Optically active pyridobenzoxazine derivatives | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1992-06-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004268-A1 | Optically Pure Dihydropyrimidine Compounds and Their Uses for the Preparation of a Medicament for Treatment and Prevention of Viral Diseases | DPYD, DHPS, DHODH | MAPT 1182/4885GPR139 4542/4885ALDH1A1 259/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.