Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.65 |
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23080142 | 0.85 | MAPT (0.71) | MAPTGPR139ALDH1A1HPGDMEN1 | |
| SCHEMBL19285674 | 0.85 | GPR139 (0.66) | MAPTGPR139ALDH1A1HPGDMEN1 | |
| SCHEMBL6083488 | 0.85 | GPR139 (0.66) | MAPTGPR139ALDH1A1HPGDMEN1 | |
| SCHEMBL12975495 | 0.85 | MAPT (0.65) | MAPTGPR139ALDH1A1HPGDMEN1 | |
| SCHEMBL12975787 | 0.85 | MAPT (0.65) | MAPTGPR139ALDH1A1HPGDMEN1 | |
| SCHEMBL7469811 | 0.85 | MAPT (0.65) | MAPTGPR139ALDH1A1HPGDMEN1 | |
| SCHEMBL23122282 | 0.83 | MAPT (0.63) | MAPTGPR139ALDH1A1HPGDMEN1 | |
| SCHEMBL3198381 | 0.83 | MAPT (0.63) | MAPTGPR139ALDH1A1HPGDMEN1 | |
| SCHEMBL2938094 | 0.83 | ALDH1A1 (0.66) | MAPTGPR139ALDH1A1HPGDMEN1 | |
| SCHEMBL25336878 | 0.83 | MAPT (0.63) | MAPTGPR139ALDH1A1HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0852226-B1 | PYRIMIDINE DERIVATIVES | KOWA CO (JP) | 2003-11-19 | — | — | EP | disclosed |
| US-5883092-A | Pyrimidine derivatives as endothelin antagonists | KOWA CO., LTD. (JP) | 1999-03-16 | — | — | US | disclosed |
| EP-0852226-A1 | PYRIMIDINE DERIVATIVES | KOWA CO. LTD. (JP) | 1998-07-08 | — | — | EP | disclosed |