Semiplenamide D

Semiplenamide D

SCHEMBL3199261

CCCCCCCCCCCCCCCCC/C=C(\C)C(=O)NC(C)COC(C)=O

nearest known ligand 0.51

Full drug profile on Sugi Atlas →

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
PRKCA P17252 1/20 0.42
LPAR3 Q9UBY5 1/20 0.41
CCR2 P41597 1/20 0.39
CNR1 P21554 1/20 0.38
EP300 Q09472 1/20 0.38
FAAH O00519 4/20 0.37
USP2 O75604 1/20 0.36
LMNA P02545 1/20 0.36
CYP3A4 P08684 1/20 0.36
MAPT P10636 1/20 0.36
RECQL P46063 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
ZDHHC7 Q9NXF8 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Semiplenamide E SCHEMBL16432052 1.00 PRKCA (0.42) PRKCALPAR3CCR2CNR1EP300
Semiplenamide C SCHEMBL16431738 0.82 CNR2 (0.50) CCR2CNR1EP300MAPT
SCHEMBL14691623 0.79 EP300 (0.44) CCR2EP300FAAHMAPTSMN1; SMN2
SCHEMBL28271939 0.74 FAAH (0.43) CCR2EP300FAAHSMN1; SMN2
SCHEMBL21903331 0.73 TSHR (0.46) PRKCAEP300FAAHMAPTZDHHC7
Acetic Acid Isobutyl Ester SCHEMBL27784547 0.73 ALDH1A1 (0.52) PRKCAFAAHLMNAMAPT
SCHEMBL7676996 0.72 EP300 (0.50) CCR2EP300FAAHUSP2LMNA
SCHEMBL647032 0.71 EP300 (0.48) CCR2EP300FAAHUSP2LMNA
SCHEMBL9998467 0.70 FAAH (0.46) PRKCAEP300FAAH
SCHEMBL9998322 0.70 FAAH (0.46) PRKCAEP300FAAH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11421223-B2 Processes and host cells for genome, pathway, and biomolecular engineering ENEVOLV, INC. (US) 2022-08-23 US disclosed
US-20190309289-A1 PROCESSES AND HOST CELLS FOR GENOME, PATHWAY, AND BIOMOLECULAR ENGINEERING ENEVOLV, INC. 2019-10-10 US disclosed
US-9944925-B2 Processes and host cells for genome, pathway, and biomolecular engineering ENEVOLV, INC. 2018-04-17 US disclosed
US-20160186168-A1 PROCESSES AND HOST CELLS FOR GENOME, PATHWAY, AND BIOMOLECULAR ENGINEERING ENEVOLV, INC. 2016-06-30 US disclosed
US-20100028469-A1 Extracts of Cranberry and Methods of Using Thereof HERBALSCIENCE GROUP, LLC (US) 2010-02-04 US disclosed