Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.31 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3114993 | 0.79 | PARP1 (0.43) | KDM4EMEN1KMT2APARP1IKBKB | |
| SCHEMBL3220368 | 0.76 | HTR7 (0.44) | — | |
| SCHEMBL3002690 | 0.75 | PIM1 (0.39) | KDM4EKMT2APARP1HSD17B10MAPT | |
| SCHEMBL5649760 | 0.73 | PIM1 (0.31) | KDM4EPARP1HSD17B10MAPT | |
| SCHEMBL2800956 | 0.73 | GABRP (0.37) | PARP1IKBKBLIMK1 | |
| SCHEMBL6526686 | 0.73 | PARP1 (0.31) | PARP1 | |
| SCHEMBL2825804 | 0.72 | PARP1 (0.31) | PARP1 | |
| SCHEMBL2931588 | 0.72 | LMNA (0.36) | PARP1IKBKB | |
| SCHEMBL3635703 | 0.72 | PARP1 (0.31) | PARP1 | |
| SCHEMBL3376017 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7683097-B2 | Topoisomerase inhibitors | Propharmacon Inc. (US) | 2010-03-23 | — | — | US | claimed |
| WO-2006022955-A2 | TOPOISOMERASE INHIBITORS | PROPHARMACON, INC. (US) | 2006-03-02 | — | — | WO | disclosed |