Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Menthol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 known ✓ | Q7Z2W7 | 5/20 | 0.75 |
| ▸ | TRPA1 known ✓ | O75762 | 2/20 | 0.75 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Menthol SCHEMBL27829994 | 0.91 | TRPM8 (0.72) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Menthol SCHEMBL29421637 | 0.91 | TRPM8 (0.72) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Menthol SCHEMBL1664554 | 0.91 | TRPM8 (0.84) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Menthol SCHEMBL27677630 | 0.89 | TRPM8 (0.75) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Menthol SCHEMBL20586546 | 0.89 | TRPM8 (0.81) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Menthol SCHEMBL1664660 | 0.89 | TRPM8 (0.81) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Menthol SCHEMBL2125538 | 0.87 | TRPM8 (0.78) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Menthol SCHEMBL28455572 | 0.87 | TRPM8 (0.84) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Menthol SCHEMBL4583912 | 0.87 | TRPM8 (0.66) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Menthol SCHEMBL27206346 | 0.87 | TRPM8 (0.91) | TRPM8TRPA1EPHX1KCNA5TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 651 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122032439-A | Preparation method of multi-stimulus response type multi-chamber microcapsule | 北京工商大学 | 2026-05-15 | — | — | CN | claimed |
| EP-4734958-A1 | TOPICAL COMPOSITION FOR PAIN RELIEF | Kenvue Brands LLC (US) | 2026-05-06 | — | — | EP | claimed |
| US-20250332126-A1 | TOPICAL COMPOSITION FOR PAIN RELIEF | JOHNSON & JOHNSON CONSUMER INC (US) | 2025-10-30 | — | — | US | claimed |
| EP-4577188-A1 | TOPICAL COMPOSITION FOR PAIN RELIEF | Kenvue Brands LLC (US) | 2025-07-02 | — | — | EP | claimed |
| CN-119970593-A | Sun-screening composition, application thereof and skin care product | 东烽化学(杭州)有限公司广州分公司 | 2025-05-13 | — | — | CN | claimed |
| CN-119970600-A | Antioxidant and ultraviolet-proof nursing composition and preparation method thereof | 厦门稀土材料研究所 | 2025-05-13 | — | — | CN | claimed |
| CN-119745776-A | Essence and preparation method thereof | 斐缦(长春)医药生物科技有限责任公司 | 2025-04-04 | — | — | CN | claimed |
| CN-119768152-A | Topical composition for pain relief | 科赴品牌有限责任公司 | 2025-04-04 | — | — | CN | claimed |
| CN-119745767-A | Dark circle-fading composition containing camellia chrysantha extract, and preparation method and application thereof | 诺德溯源(广州)生物科技有限公司 | 2025-04-04 | — | — | CN | claimed |
| CN-119679632-A | Composition containing snowflake particles, moisturizing essence and preparation method thereof | 广东诗妃化妆品有限公司 | 2025-03-25 | — | — | CN | claimed |
| CN-105395373-B | A kind of sheet microcapsules | 重庆小丸科贸有限公司 | 2018-07-27 | — | — | CN | claimed |
| CN-108272680-A | It is a kind of to repair tender skin jelly film and preparation method thereof | 广州科玛大健康产业有限公司 | 2018-07-13 | — | — | CN | claimed |
| CN-108261349-A | Tooth whitening liquid | 山东美齿汇医疗科技有限公司 | 2018-07-10 | — | — | CN | claimed |
| CN-108261357-A | A kind of novel face cleaning beans and preparation method thereof | 广州芬臣生物科技有限公司 | 2018-07-10 | — | — | CN | claimed |
| CN-105395378-B | A kind of sheet microcapsules containing refrigerant formula | 重庆小丸科贸有限公司 | 2018-07-10 | — | — | CN | claimed |
| EP-3342418-A1 | ACNE REMOVING SKIN CARE PRODUCT AND PREPARATION METHOD THEREOF | Infinitus (China) Company Ltd. (CN) | 2018-07-04 | — | — | EP | claimed |
| US-20170354834-A1 | ACNE REMOVING SKIN CARE PRODUCT AND PREPARATION METHOD THEREOF | INFINITUS (CHINA) COMPANY LTD. (CN) | 2017-12-14 | — | — | US | claimed |
| CN-105456066-A | Novel face-cleansing composition and preparation method of finished product of face-cleansing composition | PENG ZAIHUI | 2016-04-06 | — | — | CN | claimed |
| US-7078050-B2 | White cream bacteriostats, fungicide as vehicle for drug; receptivity | FUSCO NORMAJEAN | 2006-07-18 | — | — | US | claimed |
| US-20050053595-A1 | Composition for topical treatment | FUSCO NORMAJEAN (US) | 2005-03-10 | — | — | US | claimed |