Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Menthol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 known ✓ | Q7Z2W7 | 5/20 | 0.84 |
| ▸ | TRPA1 known ✓ | O75762 | 2/20 | 0.84 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.55 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Menthol SCHEMBL20586546 | 0.94 | TRPM8 (0.81) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Menthol SCHEMBL1664660 | 0.94 | TRPM8 (0.81) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Menthol SCHEMBL583696 | 0.93 | TRPM8 (0.72) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Levomenthol SCHEMBL2961481 | 0.93 | TRPM8 (0.72) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Menthol SCHEMBL2125538 | 0.92 | TRPM8 (0.78) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Menthol SCHEMBL28455572 | 0.92 | TRPM8 (0.84) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| (+)-Menthol SCHEMBL1709231 | 0.92 | TRPM8 (1.00) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Racementhol SCHEMBL521946 | 0.92 | TRPM8 (1.00) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| (+)-Menthol SCHEMBL9968934 | 0.92 | TRPM8 (1.00) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Menthol SCHEMBL20771511 | 0.92 | TRPM8 (1.00) | TRPM8TRPA1EPHX1KCNA5TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119015152-A | Composition containing menthol carbonate precursor compound and use thereof | 重庆医科大学 | 2024-11-26 | — | — | CN | claimed |
| CN-118812470-A | Menthol carbonate precursor compound and synthesis method thereof | 重庆医科大学 | 2024-10-22 | — | — | CN | claimed |
| CN-114516797-B | Methyl cyclopentenolone menthol carbonate spice and synthetic method and application thereof | 安徽中烟工业有限责任公司 | 2023-09-08 | — | — | CN | claimed |
| CN-114516797-A | Methyl cyclopentenolone menthol carbonate spice as well as synthesis method and application thereof | 安徽中烟工业有限责任公司 | 2022-05-20 | — | — | CN | claimed |
| CN-113979864-A | One-pot synthesis method of novel menthol carbonate cooling agent and application of novel menthol carbonate cooling agent in cigarettes | 云南中烟工业有限责任公司 | 2022-01-28 | — | — | CN | claimed |
| CN-111517957-B | Perilla alcohol and menthol carbonate spice | 北京工商大学 | 2022-01-25 | — | — | CN | claimed |
| CN-108360256-B | Liquid temporary solid material and preparation method and application thereof | 上海大学 | 2020-04-14 | — | — | CN | claimed |
| CN-118812470-B | Menthol carbonate precursor compound and synthesis method thereof | 重庆医科大学 | 2025-09-05 | — | — | CN | disclosed |
| CN-119015152-A | Composition containing menthol carbonate precursor compound and use thereof | 重庆医科大学 | 2024-11-26 | — | — | CN | disclosed |
| CN-119015152-A | Composition containing menthol carbonate precursor compound and use thereof | 重庆医科大学 | 2024-11-26 | — | — | CN | disclosed |
| CN-119015152-A | Composition containing menthol carbonate precursor compound and use thereof | 重庆医科大学 | 2024-11-26 | — | — | CN | disclosed |
| CN-118812470-A | Menthol carbonate precursor compound and synthesis method thereof | 重庆医科大学 | 2024-10-22 | — | — | CN | disclosed |
| CN-118812470-A | Menthol carbonate precursor compound and synthesis method thereof | 重庆医科大学 | 2024-10-22 | — | — | CN | disclosed |
| WO-2006034495-A2 | METHODS OF USING MENTHOL PROPYLENEGLYCOL-CARBONATE AND ANALOGS THEREOF FOR PRODUCING ANTI-INFLAMMATORY AND ANTI-ANGIOGENIC EFFECTS | MATIAS JONATHAN R (US) | 2006-03-30 | — | — | WO | disclosed |
| WO-2005077521-A1 | COATED SHERICAL SEAMLESS FILLED CAPSULES | SYMRISE GMBH & CO. KG (DE) | 2005-08-25 | — | — | WO | disclosed |
| WO-2005025313-A1 | MENTHOL PROPYLENEGLYCOL-CARBONATE AND ANALOGS THEREOF AS INSECT PEST REPELLENTS. | POSEIDON OCEAN SCIENCES (US) | 2005-03-24 | — | — | WO | disclosed |
| CN-1487829-A | Chewing gums and related products that provide breath freshening characteristics | WM������JR����˾ | 2004-04-07 | — | — | CN | disclosed |
| US-6506368-B2 | Encapsulating a mixture of a lipophilic core material and an oil-soluble dye, wherein said dye is D&C Green No. 6 or guaizulene or mixture of two dyes | HAARMANN & REIMBER GMBH (DE) | 2003-01-14 | — | — | US | disclosed |
| US-20020159957-A1 | Process for producing blue microcapsules | SYMRISE AG (DE) | 2002-10-31 | — | — | US | disclosed |
| US-6359168-B1 | ORGANOLEPTIC | FIRMENICH SA (CH) | 2002-03-19 | — | — | US | disclosed |