Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Menthol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 known ✓ | Q7Z2W7 | 5/20 | 0.81 |
| ▸ | TRPA1 known ✓ | O75762 | 2/20 | 0.81 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.53 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Menthol SCHEMBL1664554 | 0.94 | TRPM8 (0.84) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Menthol SCHEMBL20586546 | 0.92 | TRPM8 (0.81) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Menthol SCHEMBL13730660 | 0.92 | TRPM8 (0.68) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Menthol SCHEMBL2125538 | 0.91 | TRPM8 (0.78) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Menthol SCHEMBL2124686 | 0.91 | TRPM8 (0.78) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Menthol SCHEMBL28455572 | 0.90 | TRPM8 (0.84) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| (+)-Menthol SCHEMBL10072505 | 0.90 | TRPM8 (1.00) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| (+)-Menthol SCHEMBL12646785 | 0.90 | TRPM8 (1.00) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| (+)-Menthol SCHEMBL15449169 | 0.90 | TRPM8 (1.00) | TRPM8TRPA1EPHX1KCNA5TRPV1 | |
| Menthol SCHEMBL20771511 | 0.90 | TRPM8 (1.00) | TRPM8TRPA1EPHX1KCNA5TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 106 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260114787-A1 | Olfactory Diagnostic Compositions and Kits, and Methods of Making and Using the Same | UNIV KANSAS (US) | 2026-04-30 | — | — | US | claimed |
| CN-117625305-A | Preparation process of natural essential oil for joint maintenance | 香赞珈蓝(上海)健康科技有限公司 | 2024-03-01 | — | — | CN | claimed |
| CN-114504511-B | Powdery cosmetic composition | 上海百雀羚生物科技有限公司 | 2024-02-23 | — | — | CN | claimed |
| CN-114504511-A | Powdery cosmetic composition | 上海百雀羚生物科技有限公司 | 2022-05-17 | — | — | CN | claimed |
| CN-114469771-A | Multifunctional anti-dandruff refreshing shampoo and preparation method thereof | 上海章华保健化妆品有限公司 | 2022-05-13 | — | — | CN | claimed |
| US-20220047476-A1 | A METHOD FOR FIGHTING FEMALE BODY ODORS | SYMRISE AG (DE) | 2022-02-17 | — | — | US | claimed |
| CN-113599569-A | Bioabsorbable collagen-based medical glue and preparation method thereof | 南通伊诺精密塑胶导管有限公司 | 2021-11-05 | — | — | CN | claimed |
| CN-111802409-B | Broad-spectrum antiviral antibacterial disinfectant and preparation method and application thereof | 武汉理工大学 | 2021-10-29 | — | — | CN | claimed |
| CN-112955230-A | A method for resisting female body odor | 西姆莱斯股份公司 | 2021-06-11 | — | — | CN | claimed |
| CN-109030459-B | Method for rapidly detecting menthol content based on Raman spectrum | 天津市天大赛达协同创新科技研究院有限公司 | 2021-03-16 | — | — | CN | claimed |
| CN-111802409-A | Broad-spectrum antiviral antibacterial disinfectant and preparation method and application thereof | 武汉理工大学 | 2020-10-23 | — | — | CN | claimed |
| CN-111166702-A | Temperature-sensitive skin firming cream | 广州珂菲施诺生物科技有限公司 | 2020-05-19 | — | — | CN | claimed |
| CN-110628290-A | Formula and manufacturing method of cool butyronitrile gloves | 山东英科医疗制品有限公司 | 2019-12-31 | — | — | CN | claimed |
| CN-109030459-A | A method of menthol content is quickly detected based on Raman spectrum | 天津市天大赛达协同创新科技研究院有限公司 | 2018-12-18 | — | — | CN | claimed |
| US-20170014463-A1 | Composition Comprising Plants Extracts that Synergistically Treat or Inhibit Pathological Conditions and Method of Making | NOLAN BRUCE (US) | 2017-01-19 | — | — | US | claimed |
| US-20080032913-A1 | Masking of mineral oil odor and fragrancing of mineral oils | SYMRISE GMBH & CO. KG (DE) | 2008-02-07 | — | — | US | claimed |
| US-20050042308-A1 | Pharmaceutical composition having cholagogic and litholytic effect and its preparation method | JIANGSU KANION PHARMACEUTICALS CO., LTD. (CN) | 2005-02-24 | — | — | US | claimed |
| US-20260114787-A1 | Olfactory Diagnostic Compositions and Kits, and Methods of Making and Using the Same | UNIV KANSAS (US) | 2026-04-30 | — | — | US | disclosed |
| US-5397573-A | Side effect reduction | THE PROCTER & GAMBLE COMPANY (US) | 1995-03-14 | — | — | US | disclosed |
| WO-1990008553-A1 | TRANSDERMAL DRUG DELIVERY COMPOSITION | ABBOTT LABORATORIES (US) | 1990-08-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260114787-A1 | Olfactory Diagnostic Compositions and Kits, and Methods of Making and Using the Same | OR51E2, OR10J3, TAS2R5 | TRPM8 268/4885TRPA1 33/4885EPHX1 73/4885 |
| US-20220047476-A1 | A METHOD FOR FIGHTING FEMALE BODY ODORS | SHBG, C5, CUTA | TRPM8 2189/4885TRPA1 1305/4885EPHX1 2118/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.