Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | BACE1 | P56817 | 1/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3200550 | 0.85 | ALDH1A1 (0.63) | ALDH1A1L3MBTL1BACE1CA9NPSR1 | |
| SCHEMBL3206103 | 0.80 | BACE1 (0.80) | ALDH1A1BACE1NPSR1LMNAMAPK1 | |
| SCHEMBL3206113 | 0.80 | BACE1 (0.80) | ALDH1A1BACE1NPSR1LMNAMAPK1 | |
| SCHEMBL6438701 | 0.79 | ALDH1A1 (0.62) | ALDH1A1L3MBTL1BACE1KEAP1NFE2L2 | |
| SCHEMBL15474765 | 0.79 | ALDH1A1 (0.61) | ALDH1A1L3MBTL1BACE1CA9NR1H2 | |
| SCHEMBL3218793 | 0.78 | ALDH1A1 (0.68) | ALDH1A1L3MBTL1BACE1KEAP1NFE2L2 | |
| SCHEMBL15065176 | 0.77 | HTR1A (0.50) | ALDH1A1HTR1ADRD2LMNAIKBKB | |
| SCHEMBL8501851 | 0.77 | HTR1A (0.57) | ALDH1A1L3MBTL1HTR1ADRD2LMNA | |
| SCHEMBL5146907 | 0.77 | ALDH1A1 (0.74) | ALDH1A1L3MBTL1BACE1CA9NPSR1 | |
| SCHEMBL3200647 | 0.76 | ALDH1A1 (0.58) | ALDH1A1L3MBTL1BACE1CA9NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8962674-B2 | Curcumin derivative | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 2015-02-24 | — | — | US | disclosed |
| US-20100048901-A1 | NOVEL CURCUMIN DERIVATIVE | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 2010-02-25 | — | — | US | disclosed |
| EP-2123637-A1 | NOVEL CURCUMIN DERIVATIVE | Tokyo Institute of Technology (JP) | 2009-11-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048901-A1 | NOVEL CURCUMIN DERIVATIVE | BACE1, APP, BACE2 | ALDH1A1 253/4885L3MBTL1 2164/4885BACE1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.