Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.59 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.55 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.55 |
| ▸ | KMO | O15229 | 2/20 | 0.55 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.49 |
| ▸ | RXRA | P19793 | 2/20 | 0.49 |
| ▸ | RXRB | P28702 | 2/20 | 0.49 |
| ▸ | TYMS | P04818 | 1/20 | 0.48 |
| ▸ | DDT | P30046 | 1/20 | 0.48 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.47 |
| ▸ | TTR | P02766 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3852306 | 0.98 | NR1H4 (0.58) | NR1H4AKR1C3AKR1C2KMOFOLH1 | |
| SCHEMBL3716976 | 0.88 | AKR1C3 (0.57) | NR1H4AKR1C3AKR1C2KMOFOLH1 | |
| SCHEMBL2995452 | 0.88 | NR1H4 (0.74) | NR1H4AKR1C3AKR1C2KMOFOLH1 | |
| Benzoic Acid SCHEMBL28364522 | 0.88 | NR1H4 (0.50) | NR1H4AKR1C3AKR1C2KMORXRA | |
| SCHEMBL30516532 | 0.87 | CNR2 (0.56) | NR1H4KMOLMNAFFAR1 | |
| SCHEMBL29116857 | 0.87 | CNR2 (0.56) | NR1H4KMOLMNAFFAR1 | |
| SCHEMBL10884048 | 0.86 | NR1H4 (0.49) | NR1H4AKR1C3AKR1C2FFAR1 | |
| SCHEMBL23581248 | 0.85 | NR1H4 (0.58) | NR1H4AKR1C3AKR1C2KMOFOLH1 | |
| SCHEMBL3135455 | 0.85 | PARP1 (0.53) | NR1H4 | |
| SCHEMBL28372111 | 0.84 | AKR1C3 (0.63) | NR1H4AKR1C3AKR1C2KMOFOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7674938-B2 | Amino alcohol derivatives, pharmaceutical compositions containing the same, and use thereof | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2010-03-09 | — | — | US | disclosed |
| US-20090030218-A1 | Method For Producing Aminoalcohol Derivative Having Biphenyl Group | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2009-01-29 | — | — | US | disclosed |
| US-20080076826-A1 | POLYMORPHIC CRYSTAL OF 4'-{2-[ (1S, 2R) - 2- HYDROXY -2- (4-HYDROXYPHENYL) -1- METHYLETHYLAMINO] ETHOXY} - 3 - ISOPROPYL-3', 5' -DIMETHYLBIPHENYL - 4 - CARBOXYLIC ACID HYDROCHLORIDE | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2008-03-27 | — | — | US | disclosed |
| EP-1697339-A1 | 3-(4-BENZYLOXYPHENYL)PROPANOIC ACID DERIVATIVES | Takeda Pharmaceutical Company Limited (JP) | 2006-09-06 | — | — | EP | disclosed |
| EP-1611089-A2 | HYDROXYETHYLAMINE COMPOUNDS HAVING ASP2 INHIBITORY ACTIVITY FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LIMITED (GB) | 2006-01-04 | — | — | EP | disclosed |
| WO-2005063729-A1 | 3-(4-BENZYLOXYPHENYL)PROPANOIC ACID DERIVATIVES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-07-14 | — | — | WO | disclosed |
| WO-2004080376-A2 | HYDROXYETHYLAMINE COMPOUNDS HAVING ASP2 INHIBITORY ACTIVITY FOR THE TREATMENT OF ALZHEIMER’S DISEASE | GLAXO GROUP LIMITED (GB) | 2004-09-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090030218-A1 | Method For Producing Aminoalcohol Derivative Having Biphenyl Group | ALDH7A1, DDC, ADH5 | NR1H4 494/4885AKR1C3 96/4885AKR1C2 105/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.