Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.60 |
| ▸ | MCOLN3 | Q8TDD5 | 3/20 | 0.60 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | PKM | P14618 | 5/20 | 0.52 |
| ▸ | PKLR | P30613 | 1/20 | 0.51 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.51 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3219555 | 0.86 | HSD11B1 (0.64) | LMNAHSD11B1TSHRMEN1KMT2A | |
| SCHEMBL3205508 | 0.84 | KMT2A (0.54) | HSD11B1TSHRMEN1KMT2AKDM4E | |
| SCHEMBL3223484 | 0.83 | HTR2A (0.53) | LMNATSHRPKMPKLRMEN1 | |
| SCHEMBL3210171 | 0.83 | RBP4 (0.61) | LMNAHSD11B1PKMPKLRKMT2A | |
| SCHEMBL3213922 | 0.83 | HSD11B1 (0.67) | LMNAMCOLN3HSD11B1TSHRPKM | |
| SCHEMBL3209386 | 0.83 | HSD11B1 (0.55) | LMNAHSD11B1PKMMEN1KMT2A | |
| SCHEMBL3215762 | 0.83 | GPR183 (0.53) | HSD11B1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL3225759 | 0.83 | RBP4 (0.46) | HSD11B1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL3224467 | 0.82 | HSD11B1 (0.57) | HSD11B1PKMPKLRMEN1KMT2A | |
| SCHEMBL3225970 | 0.82 | MEN1 (0.56) | MEN1KMT2AMAPTRBP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029648-A1 | 11-Beta HSD1 Inhibitors | XIANG JASON SHAOYUN | 2010-02-04 | — | — | US | disclosed |
| US-7632838-B2 | 11-beta HSD1 inhibitors | WYETH (US) | 2009-12-15 | — | — | US | disclosed |
| US-20070219198-A1 | 11-Beta HSD 1 inhibitors | WYETH (US) | 2007-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029648-A1 | 11-Beta HSD1 Inhibitors | HSD11B1, HSD3B1, HSD11B2 | LMNA 3748/4885MCOLN3 4442/4885HSD11B1 1/4885 |
| US-20070219198-A1 | 11-Beta HSD 1 inhibitors | HSD11B1, HSD11B2, HSD3B1 | LMNA 3681/4885MCOLN3 4525/4885HSD11B1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.