Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 5/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 2/20 | 0.46 |
| ▸ | MMP8 | P22894 | 2/20 | 0.44 |
| ▸ | MMP3 | P08254 | 1/20 | 0.44 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3201870 | 0.81 | HTR2C (0.49) | SMN1; SMN2KDM4EHTR2CKCNH2HTR2A | |
| SCHEMBL3213866 | 0.81 | HTR2C (0.55) | SMN1; SMN2HTR2CKCNH2HTR2AMEN1 | |
| SCHEMBL3212101 | 0.80 | MCOLN3 (0.61) | SMN1; SMN2KDM4ETSHRHTR2CKCNH2 | |
| SCHEMBL3222016 | 0.79 | HTR2C (0.49) | SMN1; SMN2KDM4EHTR2CKCNH2HTR2A | |
| SCHEMBL3212629 | 0.78 | MEN1 (0.59) | SMN1; SMN2TSHRHTTHTR2CKCNH2 | |
| SCHEMBL3209965 | 0.78 | LMNA (0.58) | SMN1; SMN2CYP3A4HTR2CKCNH2HTR2A | |
| SCHEMBL3225853 | 0.78 | CNR1 (0.54) | SMN1; SMN2L3MBTL1HTR2CKCNH2HTR2A | |
| SCHEMBL3221859 | 0.76 | MEN1 (0.60) | SMN1; SMN2KDM4EHTTHTR2CKCNH2 | |
| SCHEMBL27750066 | 0.76 | SMN1; SMN2 (0.67) | SMN1; SMN2KDM4ETSHRCYP3A4CYP2C19 | |
| SCHEMBL5435039 | 0.75 | SMN1; SMN2 (0.54) | SMN1; SMN2KDM4ETSHRCYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029648-A1 | 11-Beta HSD1 Inhibitors | XIANG JASON SHAOYUN | 2010-02-04 | — | — | US | disclosed |
| US-7632838-B2 | 11-beta HSD1 inhibitors | WYETH (US) | 2009-12-15 | — | — | US | disclosed |
| US-20070219198-A1 | 11-Beta HSD 1 inhibitors | WYETH (US) | 2007-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029648-A1 | 11-Beta HSD1 Inhibitors | HSD11B1, HSD3B1, HSD11B2 | SMN1; SMN2 3575/4885KDM4E 1296/4885TSHR 3335/4885 |
| US-20070219198-A1 | 11-Beta HSD 1 inhibitors | HSD11B1, HSD11B2, HSD3B1 | SMN1; SMN2 3686/4885KDM4E 1360/4885TSHR 2942/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.