Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 7/20 | 0.58 |
| ▸ | HTR6 | P50406 | 2/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.47 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.47 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.47 |
| ▸ | F13A1 | P00488 | 1/20 | 0.47 |
| ▸ | TGM2 | P21980 | 1/20 | 0.47 |
| ▸ | TGM1 | P22735 | 1/20 | 0.47 |
| ▸ | TGM3 | Q08188 | 1/20 | 0.47 |
| ▸ | GBA1 | P04062 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | COMT | P21964 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3215996 | 0.84 | HSD11B1 (0.69) | HSD11B1 | |
| SCHEMBL3224518 | 0.79 | HSD11B1 (0.65) | HSD11B1F13A1TGM2TGM1TGM3 | |
| SCHEMBL3221605 | 0.78 | HSD11B1 (0.64) | HSD11B1F13A1TGM2TGM1TGM3 | |
| SCHEMBL3201987 | 0.78 | HSD11B1 (0.64) | HSD11B1F13A1TGM2TGM1TGM3 | |
| SCHEMBL3217908 | 0.76 | HSD11B1 (0.58) | HSD11B1ABCB1ABCC1ABCG2F13A1 | |
| SCHEMBL3224595 | 0.75 | HSD11B1 (0.66) | HSD11B1GBA1 | |
| SCHEMBL3223586 | 0.74 | HSD11B1 (0.72) | HSD11B1F13A1TGM2TGM1TGM3 | |
| SCHEMBL3223804 | 0.73 | HSD11B1 (0.79) | HSD11B1F13A1TGM2TGM1TGM3 | |
| SCHEMBL3225781 | 0.73 | HSD11B1 (0.60) | HSD11B1F13A1TGM2TGM1TGM3 | |
| SCHEMBL12626562 | 0.73 | HTR6 (0.52) | HTR6ALDH1A1SMN1; SMN2POLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029648-A1 | 11-Beta HSD1 Inhibitors | XIANG JASON SHAOYUN | 2010-02-04 | — | — | US | disclosed |
| US-7632838-B2 | 11-beta HSD1 inhibitors | WYETH (US) | 2009-12-15 | — | — | US | disclosed |
| US-20070219198-A1 | 11-Beta HSD 1 inhibitors | WYETH (US) | 2007-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029648-A1 | 11-Beta HSD1 Inhibitors | HSD11B1, HSD3B1, HSD11B2 | HSD11B1 1/4885HTR6 2021/4885ABCB1 781/4885 |
| US-20070219198-A1 | 11-Beta HSD 1 inhibitors | HSD11B1, HSD11B2, HSD3B1 | HSD11B1 1/4885HTR6 1213/4885ABCB1 610/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.