Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.42 |
| ▸ | GPR183 | P32249 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 3/20 | 0.40 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | MTOR | P42345 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL133993 | 0.92 | GRM5 (0.40) | GPR119GPR183GRM5SCD5KDM1A | |
| SCHEMBL15673719 | 0.90 | GPR119 (0.45) | GPR119GPR183GRM5SCD5USP30 | |
| SCHEMBL136314 | 0.90 | GRM5 (0.51) | GPR119GPR183GRM5SCD5USP30 | |
| SCHEMBL15673214 | 0.89 | SCD5 (0.44) | GPR119GPR183SCD5USP30CYP11B2 | |
| SCHEMBL135469 | 0.85 | FFAR1 (0.36) | GRM5 | |
| SCHEMBL136382 | 0.84 | GPR119 (0.46) | GPR119SCD5CYP11B2 | |
| SCHEMBL15673738 | 0.82 | GPR119 (0.41) | GPR119GPR183GRM5 | |
| SCHEMBL15673532 | 0.82 | GRM5 (0.40) | GPR119GPR183GRM5 | |
| SCHEMBL326350 | 0.81 | GRM5 (0.54) | GPR119GPR183GRM5SCD5USP30 | |
| SCHEMBL15673640 | 0.81 | GPR119 (0.40) | GPR119GPR183GRM5SCD5PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590985-B1 | NOVEL SPIROHETEROCYCLIC COMPOUNDS AS MGLU5 ANTAGONISTS | RECORDATI IRELAND LTD (IE) | 2014-05-14 | — | — | EP | disclosed |
| EP-2590985-A1 | NOVEL SPIROHETEROCYCLIC COMPOUNDS AS MGLU5 ANTAGONISTS | Recordati Ireland Limited (IE) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012004400-A1 | NOVEL SPIROHETEROCYCLIC COMPOUNDS AS MGLU5 ANTAGONISTS | RECORDATI IRELAND LIMITED (IE) | 2012-01-12 | — | — | WO | disclosed |