Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 14/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.37 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | GPR183 | P32249 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL136192 | 0.86 | GRM5 (0.40) | GRM5CYP1A2CYP3A4 | |
| SCHEMBL15673214 | 0.84 | SCD5 (0.44) | GPR119JAK2JAK1CYP11B2SCD5 | |
| SCHEMBL319557 | 0.82 | GPR119 (0.43) | GRM5GPR119CYP11B2SCD5GPR183 | |
| SCHEMBL320350 | 0.81 | GPR119 (0.42) | GRM5GPR119CYP11B2SCD5GPR183 | |
| SCHEMBL136314 | 0.81 | GRM5 (0.51) | GRM5CYP3A4GPR119JAK2JAK1 | |
| SCHEMBL15673719 | 0.81 | GPR119 (0.45) | GRM5CYP3A4GPR119SCD5GPR183 | |
| SCHEMBL136382 | 0.78 | GPR119 (0.46) | GPR119JAK2JAK1CYP11B2SCD5 | |
| SCHEMBL15673630 | 0.77 | GPR119 (0.48) | GRM5GPR119SCD5GPR183 | |
| SCHEMBL15673640 | 0.75 | GPR119 (0.40) | GRM5GPR119JAK2JAK1SCD5 | |
| SCHEMBL15673657 | 0.73 | USP2 (0.38) | GRM5GPR119GPR183 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590985-B1 | NOVEL SPIROHETEROCYCLIC COMPOUNDS AS MGLU5 ANTAGONISTS | RECORDATI IRELAND LTD (IE) | 2014-05-14 | — | — | EP | disclosed |
| EP-2590985-A1 | NOVEL SPIROHETEROCYCLIC COMPOUNDS AS MGLU5 ANTAGONISTS | Recordati Ireland Limited (IE) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012004400-A1 | NOVEL SPIROHETEROCYCLIC COMPOUNDS AS MGLU5 ANTAGONISTS | RECORDATI IRELAND LIMITED (IE) | 2012-01-12 | — | — | WO | disclosed |