Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA4 | P48058 | 10/20 | 0.49 |
| ▸ | GRIA2 | P42262 | 10/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3794324 | 1.00 | GRIA4 (0.49) | GRIA4GRIA2KCNH2KDM1A | |
| SCHEMBL3185811 | 0.87 | GRIA4 (0.57) | GRIA4GRIA2KCNH2KDM1A | |
| SCHEMBL3197386 | 0.85 | GRIA4 (0.52) | GRIA4GRIA2KCNH2KDM1A | |
| SCHEMBL3192427 | 0.84 | GRIA4 (0.47) | GRIA4GRIA2KCNH2KDM1A | |
| SCHEMBL3192440 | 0.84 | GRIA4 (0.47) | GRIA4GRIA2KCNH2KDM1A | |
| SCHEMBL3192449 | 0.84 | GRIA4 (0.47) | GRIA4GRIA2KCNH2KDM1A | |
| SCHEMBL3186437 | 0.79 | GRIA4 (0.67) | GRIA4GRIA2KCNH2KDM1A | |
| SCHEMBL3205035 | 0.79 | GRIA2 (0.52) | GRIA4GRIA2KCNH2 | |
| SCHEMBL3204407 | 0.76 | GRIA4 (0.71) | GRIA4GRIA2KCNH2 | |
| SCHEMBL3791607 | 0.73 | GPR88 (0.39) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100035865-A1 | Sulfonamides and Pharmaceutical Compositions Thereof | PFIZER INC | 2010-02-11 | — | — | US | disclosed |
| EP-2142505-A1 | SULFONAMIDES AND PHARMACEUTICAL COMPOSITIONS THEREOF | Pfizer, Inc. (US) | 2010-01-13 | — | — | EP | disclosed |
| WO-2008120093-A1 | SULFONAMIDES AND PHARMACEUTICAL COMPOSITIONS THEREOF | PFIZER INC. (US) | 2008-10-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035865-A1 | Sulfonamides and Pharmaceutical Compositions Thereof | STS, SULT2A1, SULT1A1 | GRIA4 3473/4885GRIA2 3748/4885KCNH2 1167/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.