Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CDK4 | P11802 | 4/20 | 0.39 |
| ▸ | CCND1 | P24385 | 4/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | DHFR | P00374 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29617408 | 0.95 | TSHR (0.46) | TSHRALDH1A1CDK4CCND1ALOX15 | |
| SCHEMBL3334839 | 0.95 | TSHR (0.46) | TSHRALDH1A1CDK4CCND1ALOX15 | |
| SCHEMBL4949474 | 0.78 | LMNA (0.39) | TSHRALDH1A1KMT2AMEN1ALOX5 | |
| SCHEMBL28696512 | 0.78 | CDK4 (0.37) | TSHRALDH1A1CDK4CCND1KMT2A | |
| SCHEMBL29493186 | 0.76 | HTR2A (0.39) | TSHRALDH1A1CDK4CCND1KMT2A | |
| SCHEMBL4954024 | 0.76 | MAOB (0.41) | TSHRALDH1A1ALOX15ALOX5 | |
| SCHEMBL28197536 | 0.75 | CDK4 (0.42) | TSHRCDK4CCND1KMT2A | |
| SCHEMBL3576716 | 0.74 | CDK4 (0.47) | TSHRALDH1A1CDK4CCND1KMT2A | |
| SCHEMBL30233726 | 0.74 | CDK4 (0.47) | TSHRALDH1A1CDK4CCND1KMT2A | |
| SCHEMBL4955326 | 0.74 | SRC (0.41) | TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7683051-B2 | Crystalline polymorph of bazedoxifene acetate | WYETH (US) | 2010-03-23 | — | — | US | disclosed |
| US-7683052-B2 | Crystalline polymorph of bazedoxifene acetate | WYETH (US) | 2010-03-23 | — | — | US | disclosed |
| EP-1732889-A1 | CRYSTALLINE POLYMORPH OF BAZEDOXIFENE ACETATE | Wyeth (US) | 2006-12-20 | — | — | EP | disclosed |
| EP-1732890-A1 | CRYSTALLINE POLYMORPH OF A BAZEDOXIFENE ACETATE | Wyeth (US) | 2006-12-20 | — | — | EP | disclosed |
| US-20050250762-A1 | Crystalline polymorph of bazedoxifene acetate | WYETH (US) | 2005-11-10 | — | — | US | disclosed |
| WO-2005100314-A1 | CRYSTALLINE POLYMORPH OF BAZEDOXIFENE ACETATE | WYETH (US) | 2005-10-27 | — | — | WO | disclosed |
| WO-2005100316-A1 | CRYSTALLINE POLYMORPH OF A BAZEDOXIFENE ACETATE | WYETH (US) | 2005-10-27 | — | — | WO | disclosed |
| US-20050227965-A1 | Crystalline polymorph of bazedoxifene acetate | WYETH (US) | 2005-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050250762-A1 | Crystalline polymorph of bazedoxifene acetate | CYP19A1, SHBG, NR5A1 | TSHR 1926/4885ALDH1A1 2374/4885CDK4 678/4885 |
| US-20050227965-A1 | Crystalline polymorph of bazedoxifene acetate | CYP19A1, SHBG, NR5A1 | TSHR 1926/4885ALDH1A1 2374/4885CDK4 678/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.