Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.69 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.69 |
| ▸ | MCL1 | Q07820 | 9/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | ALB | P02768 | 1/20 | 0.53 |
| ▸ | BCL2 | P10415 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29621784 | 1.00 | KDM4E (0.69) | KDM4EALDH1A1FOLH1MCL1HPGD | |
| SCHEMBL13701155 | 0.87 | KDM4E (0.71) | KDM4EALDH1A1FOLH1MCL1HPGD | |
| SCHEMBL5955774 | 0.86 | ALDH1A1 (0.74) | KDM4EALDH1A1FOLH1MCL1HTT | |
| SCHEMBL27616415 | 0.84 | KDM4E (0.67) | KDM4EALDH1A1FOLH1MCL1HPGD | |
| SCHEMBL7463580 | 0.84 | KDM4E (0.71) | KDM4EALDH1A1FOLH1MCL1HPGD | |
| SCHEMBL2002751 | 0.84 | FOLH1 (0.71) | KDM4EALDH1A1FOLH1MCL1HPGD | |
| SCHEMBL1093663 | 0.84 | KDM4E (0.67) | KDM4EALDH1A1FOLH1MCL1HPGD | |
| SCHEMBL6756295 | 0.83 | KDM4E (0.65) | KDM4EALDH1A1FOLH1MCL1HPGD | |
| SCHEMBL3069354 | 0.81 | KDM4E (0.68) | KDM4EALDH1A1FOLH1MCL1HPGD | |
| SCHEMBL9449744 | 0.81 | KDM4E (0.63) | KDM4EALDH1A1FOLH1MCL1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7666897-B2 | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents | SRI INTERNATIONAL (US) | 2010-02-23 | — | — | US | disclosed |
| US-20090023796-A1 | Analogs of Indole-3-Carbinol Metabolites as Chemotherapeutic and Chemopreventive Agents | SRI INTERNATIONAL (US) | 2009-01-22 | — | — | US | disclosed |
| EP-1530572-B1 | ANALOGS OF INDOLE-3-CARBINOL METABOLITES AS CHEMOTHERAPEUTIC AND CHEMOPREVENTIVE AGENTS | STANFORD RES INST INT (US) | 2008-10-15 | — | — | EP | disclosed |
| US-7429610-B2 | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents | SRI INTERNATIONAL (US) | 2008-09-30 | — | — | US | disclosed |
| US-7078427-B2 | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents | SRI INTERNATIONAL (US) | 2006-07-18 | — | — | US | disclosed |
| US-20060128785-A1 | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents | SRI INTERNATIONAL (US) | 2006-06-15 | — | — | US | disclosed |
| EP-1623985-A2 | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventative agents | Sri International (US) | 2006-02-08 | — | — | EP | disclosed |
| EP-1530572-A2 | ANALOGS OF INDOLE-3-CARBINOL METABOLITES AS CHEMOTHERAPEUTIC AND CHEMOPREVENTIVE AGENTS | Sri International (US) | 2005-05-18 | — | — | EP | disclosed |
| US-6800655-B2 | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents | SRI INTERNATIONAL | 2004-10-05 | — | — | US | disclosed |
| US-20040157906-A1 | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents | JONG LING (US) | 2004-08-12 | — | — | US | disclosed |
| WO-2004018475-A2 | ANALOGS OF INDOLE-3-CARBINOL METABOLITES AS CHEMOTHERAPEUTIC AND CHEMOPREVENTIVE AGENTS | SRI INTERNATIONAL (US) | 2004-03-04 | — | — | WO | disclosed |
| US-20040043965-A1 | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents | SRI INTERNATIONAL | 2004-03-04 | — | — | US | disclosed |
| US-5229413-A | Nervous system disorders | G. D. SEARLE & CO. (US) | 1993-07-20 | — | — | US | disclosed |
| US-5137910-A | Compositions containing indole-2-carboxylate compounds for treatment of CNS disorders | C.D. SEARLE & CO. (US) | 1992-08-11 | — | — | US | disclosed |
| EP-0396124-A2 | Compositions containing indole-2-carboxylate compounds for treatment of CNS disorders | G.D. Searle & Co. (US) | 1990-11-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060128785-A1 | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents | IDO1, CCND3, FOXM1 | KDM4E 3180/4885ALDH1A1 200/4885FOLH1 1455/4885 |
| US-20090023796-A1 | Analogs of Indole-3-Carbinol Metabolites as Chemotherapeutic and Chemopreventive Agents | IDO1, CCND3, CCNA1 | KDM4E 2301/4885ALDH1A1 216/4885FOLH1 1372/4885 |
| US-20040043965-A1 | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents | IDO1, IDO2, TPH1 | KDM4E 3192/4885ALDH1A1 134/4885FOLH1 1141/4885 |
| US-20040157906-A1 | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents | IDO1, IDO2, TPH1 | KDM4E 3192/4885ALDH1A1 134/4885FOLH1 1141/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.