Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 5/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SREBF1 | P36956 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3204089 | 0.96 | TSHR (0.40) | HRH4MAPK1TRPM8TSHRHDAC6 | |
| SCHEMBL3201995 | 0.95 | HRH4 (0.39) | HRH4MAPK1TRPM8TSHRHDAC6 | |
| SCHEMBL3205143 | 0.93 | ALDH1A1 (0.38) | MAPK1TRPM8TSHRHDAC6PARP15 | |
| SCHEMBL3218540 | 0.90 | RXRA (0.40) | HRH4MAPK1TRPM8HDAC6PARP15 | |
| SCHEMBL3125802 | 0.90 | RAB9A (0.39) | HRH4MAPK1TRPM8HDAC6PDE4A | |
| SCHEMBL3126048 | 0.89 | SREBF1 (0.41) | HRH4MAPK1TRPM8TSHRL3MBTL1 | |
| SCHEMBL3199311 | 0.88 | RXRA (0.37) | MAPK1TRPM8HDAC6PARP15PARP10 | |
| SCHEMBL3215147 | 0.88 | TSHR (0.46) | HRH4MAPK1TRPM8TP53TSHR | |
| SCHEMBL3215114 | 0.88 | HDAC6 (0.36) | MAPK1TP53TSHRHDAC6PARP15 | |
| SCHEMBL3219592 | 0.87 | NR1H2 (0.40) | HRH4TRPM8KDM4EMAPTSREBF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029689-A1 | PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2010-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029689-A1 | PHOSPHODIESTERASE 4 INHIBITORS | PDE4A, PDE4B, PDE3B | HRH4 442/4885MAPK1 1371/4885TRPM8 3474/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.