Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30349638 | 1.00 | TSHR (0.45) | TSHRL3MBTL1KMT2AOPRK1ALDH1A1 | |
| SCHEMBL30349443 | 1.00 | TSHR (0.45) | TSHRL3MBTL1KMT2AOPRK1ALDH1A1 | |
| SCHEMBL3207241 | 1.00 | TSHR (0.45) | TSHRL3MBTL1KMT2AOPRK1ALDH1A1 | |
| SCHEMBL7776122 | 0.84 | RIPK1 (0.43) | TSHRL3MBTL1KMT2AOPRK1ALDH1A1 | |
| SCHEMBL7770852 | 0.84 | RIPK1 (0.43) | TSHRL3MBTL1KMT2AOPRK1ALDH1A1 | |
| SCHEMBL30349468 | 0.82 | EPHX1 (0.57) | TSHRKMT2AALDH1A1EPHX1MAPT | |
| SCHEMBL9690162 | 0.82 | EPHX1 (0.57) | TSHRKMT2AALDH1A1EPHX1MAPT | |
| SCHEMBL9692360 | 0.81 | TSHR (0.51) | TSHRKMT2AALDH1A1KDM4ENPC1 | |
| SCHEMBL9692314 | 0.81 | TSHR (0.45) | TSHRL3MBTL1KMT2AALDH1A1KDM4E | |
| SCHEMBL7775675 | 0.80 | EPHX1 (0.46) | TSHRKMT2AALDH1A1NPC1EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7671238-B2 | Arylamino-arylpropanolamine derivatives and methods of their use | WYETH LLC (US) | 2010-03-02 | — | — | US | disclosed |
| US-20080085938-A1 | Arylamino-Arylpropanolamine Derivatives and Methods of Their Use | WYETH (US) | 2008-04-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080085938-A1 | Arylamino-Arylpropanolamine Derivatives and Methods of Their Use | PNMT, PAH, SLC18A2 | TSHR 2696/4885L3MBTL1 4375/4885KMT2A 1485/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.