Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AQP1 | P29972 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 5/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.33 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.33 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.33 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.33 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.33 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.33 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | HTR2B | P41595 | 2/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3208416 | 1.00 | AQP1 (0.39) | AQP1BRD4CREBBPALDH1A1PRKAB2 | |
| SCHEMBL3213931 | 1.00 | AQP1 (0.39) | AQP1BRD4CREBBPALDH1A1PRKAB2 | |
| SCHEMBL3199368 | 0.89 | AQP1 (0.50) | AQP1BRD4CREBBPALDH1A1PRKAB2 | |
| SCHEMBL3220781 | 0.89 | AQP1 (0.50) | AQP1BRD4CREBBPALDH1A1PRKAB2 | |
| SCHEMBL3196305 | 0.89 | AQP1 (0.50) | AQP1BRD4CREBBPALDH1A1PRKAB2 | |
| SCHEMBL3209099 | 0.87 | AQP1 (0.40) | AQP1BRD4CREBBPALDH1A1PRKAB2 | |
| SCHEMBL3203037 | 0.87 | AQP1 (0.40) | AQP1BRD4CREBBPALDH1A1PRKAB2 | |
| SCHEMBL3210782 | 0.87 | AQP1 (0.40) | AQP1BRD4CREBBPALDH1A1PRKAB2 | |
| SCHEMBL3216852 | 0.85 | PKM (0.35) | BRD4CREBBPPRKAB2PRKAG1PRKAA2 | |
| SCHEMBL3222181 | 0.85 | PKM (0.35) | BRD4CREBBPPRKAB2PRKAG1PRKAA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100035871-A1 | BENZOXAZINE DERIVATIVES AND USES THEREOF | WYETH | 2010-02-11 | — | — | US | claimed |
| US-20100035871-A1 | BENZOXAZINE DERIVATIVES AND USES THEREOF | WYETH | 2010-02-11 | — | — | US | disclosed |
| WO-2008052075-A2 | BENZOXAZINE DERIVATIVES AND USES THEREOF | WYETH (US) | 2008-05-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035871-A1 | BENZOXAZINE DERIVATIVES AND USES THEREOF | HTR2C, HTR5A, NPY1R | AQP1 2125/4885BRD4 780/4885CREBBP 980/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.