Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 10/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3218633 | 0.96 | HRH4 (0.37) | TRPM8CYP3A4PDE4APDE4BPDE4C | |
| SCHEMBL3210508 | 0.92 | TRPM8 (0.37) | TRPM8CYP3A4PDE4APDE4BPDE4C | |
| SCHEMBL3200782 | 0.88 | PDE4A (0.39) | CYP3A4PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3129231 | 0.88 | PDE4B (0.38) | PDE4APDE4BPDE4CPDE4DMAOB | |
| SCHEMBL3205713 | 0.87 | HRH4 (0.38) | TRPM8CYP3A4PDE4APDE4BPDE4C | |
| SCHEMBL3129693 | 0.87 | GRM2 (0.44) | TRPM8PDE4BGRM2 | |
| SCHEMBL3193291 | 0.83 | PCSK9 (0.39) | TRPM8PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3123327 | 0.81 | PDE4A (0.38) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3203958 | 0.81 | HRH4 (0.37) | PDE4APDE4BPDE4CPDE4DMAOB | |
| SCHEMBL3122279 | 0.80 | ALDH1A1 (0.43) | TRPM8PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029689-A1 | PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2010-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029689-A1 | PHOSPHODIESTERASE 4 INHIBITORS | PDE4A, PDE4B, PDE3B | TRPM8 3474/4885CYP3A4 48/4885PDE4A 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.