Sugi Predict

Sugi Predict / Compounds / SCHEMBL320780

SCHEMBL320780

SCHEMBL320780

O=C(Cl)c1ccc(Br)c(Cl)c1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 4/20 0.55
▸ ALDH1A1 P00352 5/20 0.45
▸ PKM P14618 1/20 0.45
▸ TSHR P16473 1/20 0.43
▸ MEN1 O00255 6/20 0.43
▸ KMT2A Q03164 6/20 0.43
▸ LMNA P02545 4/20 0.43
▸ SMN1; SMN2 Q16637 3/20 0.43
▸ HTT P42858 2/20 0.43
▸ NPC1 O15118 2/20 0.43
▸ HPGD P15428 4/20 0.42
▸ ALOX15 P16050 2/20 0.42
▸ ALOX12 P18054 2/20 0.42
▸ GAA P10253 1/20 0.39
▸ L3MBTL1 Q9Y468 1/20 0.39
▸ RAB9A P51151 2/20 0.39
▸ CYP1A2 P05177 1/20 0.39
▸ CYP3A4 P08684 1/20 0.39
▸ CYP2D6 P10635 1/20 0.39
▸ CYP2C9 P11712 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL177140 0.83 TSHR (0.65) MAPTALDH1A1PKMTSHRMEN1
SCHEMBL2964948 0.83 TSHR (0.43) MAPTALDH1A1PKMTSHRMEN1
SCHEMBL7683262 0.82 MAPT (0.40) MAPTALDH1A1PKMTSHRMEN1
SCHEMBL6139728 0.81 MAPT (0.64) MAPTALDH1A1PKMTSHRMEN1
SCHEMBL29996684 0.81 MAPT (0.64) MAPTALDH1A1PKMTSHRMEN1
SCHEMBL1439135 0.81 MAPT (0.53) MAPTALDH1A1PKMTSHRMEN1
SCHEMBL110094 0.79 TSHR (0.67) MAPTPKMTSHRMEN1KMT2A
SCHEMBL29514652 0.79 TSHR (0.67) MAPTPKMTSHRMEN1KMT2A
SCHEMBL38657986 0.79 MAPT (0.51) MAPTALDH1A1PKMTSHRMEN1
SCHEMBL2266803 0.78 MAPT (0.38) MAPTALDH1A1PKMTSHRMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 85 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260078117-A1 COMPOUNDS AND METHODS OF USE TANGO THERAPEUTICS INC (US) 2026-03-19 — — US disclosed
US-12304907-B2 Compounds and methods of use TANGO THERAPEUTICS, INC. (US) 2025-05-20 — — US disclosed
US-12281060-B2 Remodilins for airway remodeling and organ fibrosis THE UNIVERSITY OF CHICAGO (US) 2025-04-22 — — US disclosed
US-12264154-B2 Compounds and methods of use TANGO THERAPEUTICS, INC. (US) 2025-04-01 — — US disclosed
US-20240415851-A1 REMODILINS TO PREVENT OR TREAT CANCER METASTASIS, GLAUCOMA, AND HYPOXIA THE UNIVERSITY OF CHICAGO (US) 2024-12-19 — — US disclosed
CN-113166098-B Triazine compound, material for organic electroluminescent element, and organic electroluminescent element 东曹株式会社 2024-12-13 — — CN disclosed
US-20240279219-A1 COMPOUNDS AND METHODS OF USE TANGO THERAPEUTICS, INC. 2024-08-22 — — US disclosed
US-20240228478-A1 COMPOUNDS AND METHODS OF USE TANGO THERAPEUTICS, INC. 2024-07-11 — — US disclosed
US-20240228478-A1 COMPOUNDS AND METHODS OF USE TANGO THERAPEUTICS, INC. 2024-07-11 — — US disclosed
US-20240228478-A1 COMPOUNDS AND METHODS OF USE TANGO THERAPEUTICS, INC. 2024-07-11 — — US disclosed
WO-2010077882-A2 ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS AMIRA PHARMACEUTICALS, INC. (US) 2010-07-08 — — WO disclosed
US-20100152257-A1 ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS AMIRA PHARMACEUTICALS, INC. (US) 2010-06-17 — — US disclosed
EP-0211598-B1 Pesticidal compounds WELLCOME FOUND (GB) 1993-12-15 — — EP disclosed
WO-1993010077-A1 N,N-DI-ALKYL(PHENOXY)BENZAMIDE DERIVATIVES G.D. SEARLE & CO. (US) 1993-05-27 — — WO disclosed
US-5098929-A Insecticides, insect attractants, fungicides or oxidase inhibitors THE WELLCOME FOUNDATION LIMITED (GB) 1992-03-24 — — US disclosed
CN-86105901-A Agricultural chemical compound — 1987-03-11 — — CN disclosed
EP-0211598-A2 Pesticidal compounds ROUSSEL-UCLAF (FR) 1987-02-25 — — EP disclosed
EP-0126225-B1 PROCESS FOR THE PREPARATION OF SUBSTITUTED TRIALKYLSILYLOXYMALONIC-ACID DINITRILES BAYER AG (DE) 1986-11-26 — — EP disclosed
US-4620022-A REACTING TRIALKYLSILYL CYANIDE WITH ACID HALIDE BAYER AKTIENGESELLSCHAFT (DE) 1986-10-28 — — US disclosed
EP-0126225-A1 Process for the preparation of substituted trialkylsilyloxymalonic-acid dinitriles BAYER AG (DE) 1984-11-28 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100152257-A1 ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS LPAR1, LPAR2, LPAR4 MAPT 4253/4885ALDH1A1 3791/4885PKM 2247/4885
US-20240279219-A1 COMPOUNDS AND METHODS OF USE F12, C1R, ABCG2 MAPT 2749/4885ALDH1A1 128/4885PKM 2130/4885
US-12264154-B2 Compounds and methods of use F12, C1R, ABCG2 MAPT 2749/4885ALDH1A1 128/4885PKM 2130/4885
US-12304907-B2 Compounds and methods of use F12, C1R, ABCG2 MAPT 2749/4885ALDH1A1 128/4885PKM 2130/4885
US-12281060-B2 Remodilins for airway remodeling and organ fibrosis MYLK, MFAP1, FIBP MAPT 4699/4885ALDH1A1 3220/4885PKM 4378/4885
US-20240228478-A1 COMPOUNDS AND METHODS OF USE F12, C1R, ABCG2 MAPT 2749/4885ALDH1A1 128/4885PKM 2130/4885
US-20240415851-A1 REMODILINS TO PREVENT OR TREAT CANCER METASTASIS, GLAUCOMA, AND HYPOXIA HIF1AN, RHOXF2, HIF1A MAPT 4394/4885ALDH1A1 2857/4885PKM 3281/4885
US-20260078117-A1 COMPOUNDS AND METHODS OF USE NR3C2, ADRA1A, CNR1 MAPT 4259/4885ALDH1A1 100/4885PKM 4641/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.