SCHEMBL29514652

SCHEMBL29514652

O=C(Cl)c1ccc(Cl)c(Cl)c1

nearest known ligand 0.67

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.67
SRD5A2 P31213 1/20 0.57
MEN1 O00255 2/20 0.53
KMT2A Q03164 2/20 0.53
KDM4E B2RXH2 1/20 0.53
NPC1 O15118 1/20 0.53
MAPT P10636 1/20 0.53
PKM P14618 1/20 0.53
RAB9A P51151 1/20 0.53
KMO O15229 3/20 0.53
HPGD P15428 3/20 0.52
POLB P06746 1/20 0.50
HTT P42858 1/20 0.50
KCNQ3 O43525 1/20 0.47
KCNQ2 O43526 1/20 0.47
KCNE1 P15382 1/20 0.47
KCNQ1 P51787 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL110094 1.00 TSHR (0.67) TSHRSRD5A2MEN1KMT2AKDM4E
SCHEMBL7543655 0.83 CES2 (0.50) TSHRSRD5A2MEN1KMT2AKDM4E
SCHEMBL9812968 0.83 TSHR (0.46) TSHRSRD5A2MEN1KMT2AKDM4E
SCHEMBL23484544 0.82 AHR (0.58) TSHRSRD5A2MEN1KMT2AKDM4E
SCHEMBL6322177 0.82 SRD5A2 (0.79) TSHRSRD5A2MEN1KMT2AKDM4E
SCHEMBL3184435 0.82 TSHR (0.70) TSHRSRD5A2MEN1KMT2AKDM4E
SCHEMBL4286582 0.81 HSP90AA1 (0.55) TSHRSRD5A2KDM4EMAPTPOLB
SCHEMBL9618406 0.81 TSHR (0.45) TSHRSRD5A2MEN1KMT2AKDM4E
SCHEMBL101687 0.81 TSHR (0.45) TSHRSRD5A2MEN1KMT2AKDM4E
SCHEMBL3566736 0.81 TSHR (0.50) TSHRSRD5A2KDM4EMAPTKMO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119098067-A Method for producing reverse osmosis membrane and reverse osmosis membrane produced thereby 沃顿科技股份有限公司 2024-12-10 CN claimed
CN-117471012-A Method for detecting related substances of p-chlorobenzoyl chloride by gas chromatography 南京医科大学康达学院 2024-01-30 CN claimed
CN-114615823-A Method for improving binding force between outer-layer conductive pattern of thick copper plate and printing ink 常州澳弘电子股份有限公司 2022-06-10 CN claimed
CN-114432900-A Preparation method of anti-pollution composite reverse osmosis membrane and anti-pollution composite reverse osmosis membrane prepared by same 沃顿科技股份有限公司 2022-05-06 CN claimed
CN-112752837-B Natural killer cells 帝国理工学院创新有限公司 2026-05-15 CN disclosed
US-20250206753-A1 FUSED BICYCLIC COMPOUNDS FOR THE TREATMENT OF DISEASE ABBVIE INC. 2025-06-26 US disclosed
CN-116947688-B Benzoyl hydrazine compounds, and preparation method and application thereof 赣南师范大学 2025-06-03 CN disclosed
CN-120040420-A Heterocyclic-pyrazole amine derivatives, preparation method thereof and application thereof in resisting tubercle bacillus infection 中国医学科学院医药生物技术研究所 2025-05-27 CN disclosed
CN-119930563-A Transient receptor potential cation channel TRPV3 inhibitor and application thereof 苏中药业集团股份有限公司 2025-05-06 CN disclosed
CN-116178337-B Benzodiazepine compounds and their use as Rho kinase inhibitors 成都奥睿药业有限公司 2025-04-25 CN disclosed
CN-119638763-A Gentiopicroside amide derivative, synthetic method and application 甘肃中医药大学 2025-03-18 CN disclosed
CN-119098067-A Method for producing reverse osmosis membrane and reverse osmosis membrane produced thereby 沃顿科技股份有限公司 2024-12-10 CN disclosed
CN-116478134-A SSRI/5-HT 1A Double-target antidepressant formylpiperidine compound and preparation method and application thereof 上海医药工业研究院有限公司 2023-07-25 CN disclosed
CN-116178337-A Benzodiazepine compounds and their use as Rho kinase inhibitors 成都奥睿药业有限公司 2023-05-30 CN disclosed
CN-110734391-B 2, 3-diketone indole compound and preparation method and application thereof 山东大学 2023-05-02 CN disclosed
CN-115385902-A Benzimidazole compound and preparation method and application thereof 徐州医科大学 2022-11-25 CN disclosed
CN-114615823-A Method for improving binding force between outer-layer conductive pattern of thick copper plate and printing ink 常州澳弘电子股份有限公司 2022-06-10 CN disclosed
CN-114432900-A Preparation method of anti-pollution composite reverse osmosis membrane and anti-pollution composite reverse osmosis membrane prepared by same 沃顿科技股份有限公司 2022-05-06 CN disclosed
EP-3976620-A1 FUSED HETEROCYCLIC DERIVATIVES Janssen Sciences Ireland Unlimited Company (IE) 2022-04-06 EP disclosed
CN-114258390-A Glycolate oxidase inhibitors for disease treatment 生物马林药物股份有限公司 2022-03-29 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250206753-A1 FUSED BICYCLIC COMPOUNDS FOR THE TREATMENT OF DISEASE VHL, BRDT, PAICS TSHR 3988/4885SRD5A2 361/4885MEN1 285/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.