Ademetionine

Ademetionine

SCHEMBL3208360

CSC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O.C[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O

nearest known ligand 0.89

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CARM1 Q86X55 6/20 0.89
AMD1 P17707 4/20 0.89
PRMT1 Q99873 4/20 0.78
PRMT5 O14744 3/20 0.78
PCMT1 P22061 3/20 0.78
PRMT3 O60678 2/20 0.78
PNMT P11086 2/20 0.78
PRMT6 Q96LA8 2/20 0.78
WDR77 Q9BQA1 2/20 0.78
PRMT7 Q9NVM4 2/20 0.78
NSD3 Q9BZ95 2/20 0.78
ADORA3 P0DMS8 1/20 0.78
KDR P35968 1/20 0.78
PRMT8 Q9NR22 1/20 0.78
DOT1L Q8TEK3 5/20 0.69
NSD2 O96028 4/20 0.69
SETD7 Q8WTS6 4/20 0.69
EHMT2 Q96KQ7 3/20 0.69
NNMT P40261 3/20 0.69
FASN P49327 3/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ademetionine SCHEMBL7810282 0.94 CARM1 (1.00) CARM1AMD1PRMT1PRMT5PCMT1
Ademetionine SCHEMBL66767 0.94 CARM1 (1.00) CARM1AMD1PRMT1PRMT5PCMT1
Ademetionine SCHEMBL3202538 0.94 CARM1 (1.00) CARM1AMD1PRMT1PRMT5PCMT1
Ademetionine SCHEMBL599664 0.94 CARM1 (1.00) CARM1AMD1PRMT1PRMT5PCMT1
Ademetionine SCHEMBL59293 0.94 CARM1 (1.00) CARM1AMD1PRMT1PRMT5PCMT1
Ademetionine SCHEMBL2007787 0.94 CARM1 (1.00) CARM1AMD1PRMT1PRMT5PCMT1
Ademetionine SCHEMBL55479 0.94 CARM1 (1.00) CARM1AMD1PRMT1PRMT5PCMT1
Ademetionine SCHEMBL4164615 0.94 CARM1 (1.00) CARM1AMD1PRMT1PRMT5PCMT1
Ademetionine SCHEMBL600368 0.94 CARM1 (1.00) CARM1AMD1PRMT1PRMT5PCMT1
Ademetionine SCHEMBL13033865 0.94 CARM1 (1.00) CARM1AMD1PRMT1PRMT5PCMT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100062993-A1 Adenosine Nucleotides as Dietary Supplements and as Agents in the Prevention of Cancer and the Metastasis Thereof Bulka, Yochanan R. (US) 2010-03-11 US disclosed
US-5753213-A TREATMENT OF SCALP SEBORRHEA AND PRURITUS BIORESEARCH S.P.A. (IT) 1998-05-19 US disclosed
EP-0387756-B1 Use of 5'-deoxy-5'-methylthioadenosine s-adenosylmethionine and their salts in the preparation of seborrhea-reducing pharmaceutical compositions BIORESEARCH SPA (IT) 1994-01-12 EP disclosed
EP-0387756-A1 Use of 5'-deoxy-5'-methylthioadenosine s-adenosylmethionine and their salts in the preparation of seborrhea-reducing pharmaceutical compositions BIORESEARCH S.p.A. (IT) 1990-09-19 EP disclosed