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Ademetionine

Ademetionine

SCHEMBL599664

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nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CARM1 Q86X55 5/20 1.00
▸ AMD1 P17707 4/20 1.00
▸ PCMT1 P22061 3/20 0.87
▸ PRMT5 O14744 3/20 0.87
▸ PRMT1 Q99873 3/20 0.87
▸ NSD3 Q9BZ95 2/20 0.87
▸ PRMT3 O60678 2/20 0.87
▸ PNMT P11086 2/20 0.87
▸ PRMT6 Q96LA8 2/20 0.87
▸ WDR77 Q9BQA1 2/20 0.87
▸ PRMT7 Q9NVM4 2/20 0.87
▸ ADORA3 P0DMS8 1/20 0.87
▸ KDR P35968 1/20 0.87
▸ PRMT8 Q9NR22 1/20 0.87
▸ NNMT P40261 3/20 0.72
▸ DOT1L Q8TEK3 5/20 0.71
▸ NSD2 O96028 3/20 0.71
▸ SETD7 Q8WTS6 3/20 0.71
▸ EHMT2 Q96KQ7 3/20 0.71
▸ TRDMT1 O14717 2/20 0.71

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ademetionine SCHEMBL13033865 1.00 CARM1 (1.00) CARM1AMD1PCMT1PRMT5PRMT1
Ademetionine SCHEMBL600368 1.00 CARM1 (1.00) CARM1AMD1PCMT1PRMT5PRMT1
Ademetionine SCHEMBL66767 1.00 CARM1 (1.00) CARM1AMD1PCMT1PRMT5PRMT1
Ademetionine SCHEMBL2007787 1.00 CARM1 (1.00) CARM1AMD1PCMT1PRMT5PRMT1
Ademetionine SCHEMBL4164615 1.00 CARM1 (1.00) CARM1AMD1PCMT1PRMT5PRMT1
Ademetionine SCHEMBL55479 1.00 CARM1 (1.00) CARM1AMD1PCMT1PRMT5PRMT1
Ademetionine SCHEMBL7810282 1.00 CARM1 (1.00) CARM1AMD1PCMT1PRMT5PRMT1
Ademetionine SCHEMBL59293 1.00 CARM1 (1.00) CARM1AMD1PCMT1PRMT5PRMT1
Ademetionine SCHEMBL3202538 1.00 CARM1 (1.00) CARM1AMD1PCMT1PRMT5PRMT1
Ademetionine SCHEMBL9518716 1.00 CARM1 (1.00) CARM1AMD1PCMT1PRMT5PRMT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 72 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3648770-A1 SALT OF (SS)-ADENOSYL METHIONINE WITH INOSITOL HEXAPHOSPHATE, AND PROCESS FOR THE PREPARATION THEREOF Gnosis S.p.A. (IT) 2020-05-13 — — EP claimed
WO-2019007929-A1 SALT OF (SS)-ADENOSYL METHIONINE WITH INOSITOL HEXAPHOSPHATE, AND PROCESS FOR THE PREPARATION THEREOF GNOSIS S.P.A. (IT) 2019-01-10 — — WO claimed
US-20120040923-A1 STABLE S-ADENOSYL-L-METHIONINE HEBERT ROLLAND F (US) 2012-02-16 — — US claimed
US-20110052623-A1 DRIED MICROBIAL CELLS OR MICROORGANISM EXTRACT CONTAINING STABILIZED (SS)-S-ADENOSYL-L-METHIONINE AND METHOD FOR PRODUCTION OF THE DRIED MICROORGANISM CELL OR MICROORGANISM EXTRACT KANEKA CORPORATION (JP) 2011-03-03 — — US claimed
US-20100004191-A1 Compositions of S-adenosyl-L-methionine. HEBERT SAM-E LLC 2010-01-07 — — US claimed
US-20090012036-A1 Stable S-adenosyl-L-methionine HEBERT SAM-E LLC 2009-01-08 — — US claimed
US-7387796-B2 Stable compositions of S-adenosyl-l-methionine with dextran HEBERT SAM-E LLC 2008-06-17 — — US claimed
US-20060127506-A1 Compositions of S-adenosyl-L-methionine HEBERT SAM-E LLC 2006-06-15 — — US claimed
US-20040063660-A1 Diasteriomers of S-adenosyl-l-methionine and uses thereof HEBERT ROLLAND F (US) 2004-04-01 — — US claimed
EP-1283845-B1 PROCESS FOR THE PREPARATION OF PHARMACEUTICALLY ACCEPTABLE SALTS OF (SS-RS)-S-ADENOSYL-L-METHIONINE CHEMENTECNO SRL (IT) 2003-12-17 — — EP claimed
US-20030144244-A1 Stable compositions of S-adenosyl-l-methionine with dextran HEBERT SAM-E LLC 2003-07-31 — — US claimed
EP-1283845-A1 PROCESS FOR THE PREPARATION OF PHARMACEUTICALLY ACCEPTABLE SALTS OF (SS-RS)-S-ADENOSYL-L-METHIONINE CHEMENTECNO S.r.l. (IT) 2003-02-19 — — EP claimed
US-20020173012-A1 Process for the preparation of pharmaceutically acceptable salts of (R,S)-S-adenosyl-L-methionine BERNA MARCO (IT) 2002-11-21 — — US claimed
US-20020025926-A1 Enantiomers of S-adenosyl-l-methionine HEBERT ROLLAND F (US) 2002-02-28 — — US claimed
US-20020010147-A1 Process for the preparation of pharmaceutically acceptable salts of (SS,RS) -s-adenosyl-l-methionine CHEMENTECNO S.R.L. (IT) 2002-01-24 — — US claimed
WO-2001090130-A1 PROCESS FOR THE PREPARATION OF PHARMACEUTICALLY ACCEPTABLE SALTS OF (SS-RS)-S-ADENOSYL-L-METHIONINE CHEMENTECNO S.R.L. (IT) 2001-11-29 — — WO claimed
EP-3071191-B1 SLOW-RELEASE SOLID ORAL COMPOSITIONS GNOSIS SPA (IT) 2022-01-05 — — EP disclosed
US-10702482-B2 Slow-release solid oral compositions GNOSIS SPA (IT) 2020-07-07 — — US disclosed
EP-0191133-B2 Stable salts of SAM with polyanions GIBIPHARMA SPA (IT) 1994-08-17 — — EP disclosed
EP-0395656-B1 LIPOPHILIC SALTS OF S-ADENOSYL-L-METHIONINE (SAM) WITH ACYLATED TAURINE DERIVATIVES ZAPPIA, Vincenzo (IT) 1992-09-02 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020010147-A1 Process for the preparation of pharmaceutically acceptable salts of (SS,RS) -s-adenosyl-l-methionine SRM, CBS, BHMT2 CARM1 420/4885AMD1 6/4885PCMT1 87/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.