Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.64 |
| ▸ | PTGER3 | P43115 | 6/20 | 0.58 |
| ▸ | PTGER4 | P35408 | 6/20 | 0.58 |
| ▸ | PTGER2 | P43116 | 6/20 | 0.58 |
| ▸ | PTGER1 | P34995 | 4/20 | 0.58 |
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.53 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | APP | P05067 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.47 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3208404 | 1.00 | HDAC8 (0.64) | HDAC8PTGER3PTGER4PTGER2PTGER1 | |
| SCHEMBL5119417 | 0.89 | HDAC8 (0.61) | HDAC8PTGER3PTGER4PTGER2PTGER1 | |
| SCHEMBL3218772 | 0.89 | HDAC8 (0.65) | HDAC8PTGER3PTGER4PTGER2PTGER1 | |
| SCHEMBL5119409 | 0.89 | HDAC8 (0.61) | HDAC8PTGER3PTGER4PTGER2PTGER1 | |
| SCHEMBL3218760 | 0.89 | HDAC8 (0.65) | HDAC8PTGER3PTGER4PTGER2PTGER1 | |
| SCHEMBL7191225 | 0.89 | PTGER3 (0.68) | HDAC8PTGER3PTGER4PTGER2PTGER1 | |
| SCHEMBL7909151 | 0.89 | PTGER3 (0.68) | HDAC8PTGER3PTGER4PTGER2PTGER1 | |
| SCHEMBL27716287 | 0.88 | HDAC8 (0.64) | HDAC8PTGER3PTGER4PTGER2PTGER1 | |
| SCHEMBL6035015 | 0.88 | HDAC8 (0.80) | HDAC8PTGER3PTGER4PTGER2PTGER1 | |
| SCHEMBL6035013 | 0.88 | HDAC8 (0.80) | HDAC8PTGER3PTGER4PTGER2PTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100041892-A1 | Therapeutic agent for diabetes | ABE HIDENORI | 2010-02-18 | — | — | US | disclosed |
| US-20090270631-A1 | Therapeutic agent for diabetes | ABE HIDENORI | 2009-10-29 | — | — | US | disclosed |
| EP-1912645-A2 | THERAPEUTIC AGENT FOR DIABETES | Takeda Pharmaceutical Company Limited (JP) | 2008-04-23 | — | — | EP | disclosed |
| US-20080051418-A1 | Arylalkanoic Acid Derivative | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-02-28 | — | — | US | disclosed |
| US-20080009530-A1 | Therapeutic Agent for Diabetes | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-01-10 | — | — | US | disclosed |
| EP-1829863-A1 | ARYLALKANOIC ACID DERIVATIVE | Takeda Pharmaceutical Company Limited (JP) | 2007-09-05 | — | — | EP | disclosed |
| WO-2007018314-A2 | THERAPEUTIC AGENT FOR DIABETES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-02-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270631-A1 | Therapeutic agent for diabetes | FABP4, SLC5A1, SLC5A2 | HDAC8 789/4885PTGER3 2459/4885PTGER4 2014/4885 |
| US-20080051418-A1 | Arylalkanoic Acid Derivative | INSR, NPY1R, GPR119 | HDAC8 156/4885PTGER3 1565/4885PTGER4 1928/4885 |
| US-20080009530-A1 | Therapeutic Agent for Diabetes | FABP4, SLC5A1, SLC5A2 | HDAC8 663/4885PTGER3 2522/4885PTGER4 2098/4885 |
| US-20100041892-A1 | Therapeutic agent for diabetes | FABP4, SLC5A1, SLC5A2 | HDAC8 789/4885PTGER3 2459/4885PTGER4 2014/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.