Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.49 |
| ▸ | CETP | P11597 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3209227 | 0.87 | RAB9A (0.65) | SMN1; SMN2LMNAMAPTMEN1KMT2A | |
| SCHEMBL775160 | 0.82 | MAPT (0.56) | SMN1; SMN2LMNAMAPTMEN1KMT2A | |
| SCHEMBL3208835 | 0.80 | RAB9A (0.65) | SMN1; SMN2LMNAMAPTMEN1KMT2A | |
| SCHEMBL3199806 | 0.80 | PTPN1 (0.67) | SMN1; SMN2LMNAMAPTMEN1KMT2A | |
| SCHEMBL773730 | 0.79 | PLAU (0.62) | SMN1; SMN2LMNAMAPTMEN1KMT2A | |
| SCHEMBL3203488 | 0.79 | MAPT (0.62) | SMN1; SMN2LMNAMAPTMEN1KMT2A | |
| SCHEMBL6237411 | 0.78 | GAA (0.60) | SMN1; SMN2LMNAMAPTMEN1KMT2A | |
| SCHEMBL13742544 | 0.77 | NR1H4 (0.53) | SMN1; SMN2LMNAMAPTMEN1KMT2A | |
| SCHEMBL3973956 | 0.77 | SMN1; SMN2 (0.57) | SMN1; SMN2LMNAMAPTMEN1KMT2A | |
| SCHEMBL11361119 | 0.77 | MAPT (0.65) | SMN1; SMN2LMNAMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7683097-B2 | Topoisomerase inhibitors | Propharmacon Inc. (US) | 2010-03-23 | — | — | US | claimed |